2026-04-28T12:43:46Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/61182025-02-14T12:56:29Zcom_10259_3844com_10259_5086com_10259_2604col_10259_3845
2021-11-08T12:01:45Z
urn:hdl:10259/6118
UV/Vis absorption spectroelectrochemistry of folic acid
Olmo Alonso, Fabiola
Rodríguez Rubio, Andrea
Colina Santamaría, Álvaro
Heras Vidaurre, Aránzazu
Vitamin B9
Pharmaceutical drug
Electrochemistry
UV/Vis absorption spectroscopy
UV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information
that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel
configuration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistry
has been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowing
us to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders of
magnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. The
spectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interesting
because of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results with
very good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorption
spectroelectrochemistry.
2021-11-08T12:01:45Z
2021-11-08T12:01:45Z
2021-08
info:eu-repo/semantics/article
1433-0768
http://hdl.handle.net/10259/6118
10.1007/s10008-021-05026-5
eng
Journal of Solid State Electrochemistry. 2022, V. 26, p. 29-37
https://doi.org/10.1007/s10008-021-05026-5
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-83935-R/ES/ESPECTROELECTROQUIMICA RAMAN CUANTITATIVA
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/ RED2018-102412-T/ES/RED DE SENSORES Y BIOSENSORES ELECTROQUIMICOS
info:eu-repo/grantAgreement/Junta de Castilla y León//BU297P18
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Atribución 4.0 Internacional
Springer