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oai:riubu.ubu.es:10259/61182025-02-14T12:56:29Zcom_10259_3844com_10259_5086com_10259_2604col_10259_3845

UV/Vis absorption spectroelectrochemistry of folic acid Olmo Alonso, Fabiola Rodríguez Rubio, Andrea Colina Santamaría, Álvaro Heras Vidaurre, Aránzazu Vitamin B9 Pharmaceutical drug Electrochemistry UV/Vis absorption spectroscopy Química analítica Chemistry, Analytic UV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel configuration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistry has been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowing us to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders of magnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. The spectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interesting because of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results with very good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorption spectroelectrochemistry. Ministerio de Economía y Competitividad (Grant CTQ2017-83935-R-AEI/FEDERUE), Junta de Castilla y León (Grant BU297P18), and Ministerio de Ciencia, Innovación y Universidades (Grant RED2018-102412-T). F.O. is grateful for the contract funded by Junta de Castilla y León, the European Social Fund, and the Youth Employment Initiative. Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE 2021-11-08T12:01:45Z 2021-11-08T12:01:45Z 2021-08 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 1433-0768 http://hdl.handle.net/10259/6118 10.1007/s10008-021-05026-5 eng Journal of Solid State Electrochemistry. 2022, V. 26, p. 29-37 https://doi.org/10.1007/s10008-021-05026-5 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-83935-R/ES/ESPECTROELECTROQUIMICA RAMAN CUANTITATIVA info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/ RED2018-102412-T/ES/RED DE SENSORES Y BIOSENSORES ELECTROQUIMICOS info:eu-repo/grantAgreement/Junta de Castilla y León//BU297P18 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Springer