2026-04-28T19:29:02Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/61212022-11-11T13:56:43Zcom_10259_3844com_10259_5086com_10259_2604col_10259_3845
Spectroelectrochemical Determination of Isoprenaline in a Pharmaceutical Sample
Olmo Alonso, Fabiola
Garoz Ruiz, Jesús
Carazo, Julia
Colina Santamaría, Álvaro
Heras Vidaurre, Aránzazu
Spectroelectrochemistry
Electrochemistry
UV/Vis absorption
Drug analysis
Isoproterenol
Metabisulfite
Química analítica
Chemistry, Analytic
UV/Vis absorption spectroelectrochemistry (SEC) is a multi-response technique that has
been commonly used for the characterization of materials and the study of reaction mechanisms.
However, it has been scarcely used for quantitative purposes. SEC allows us to obtain two analytical
signals simultaneously, yielding a dual sensor in just one experiment. In the last years, our group
has developed new devices useful for analysis. In this work, a SEC device in parallel configuration,
based on optical fibers fixed on screen-printed electrodes, was used to determine isoprenaline
in a commercial drug, using both, the electrochemical and the spectroscopic signals. In this
commercial drug, isoprenaline is accompanied in solution by other compounds. Among them is
sodium metabisulfite, an antioxidant that strongly interferes in the isoprenaline determination. A
simple pretreatment of the drug sample by bubbling wet-air allows us to avoid the interference of
metabisulfite. Here, we demonstrate again the capabilities of UV/Vis absorption SEC as double sensor
for analysis and we propose a simple pretreatment to remove interfering compounds.
Ministerio de Economía y Competitividad (Grant CTQ2017-83935-R-AEI/FEDERUE), Junta de Castilla y León (Grant BU297P18), and Ministerio de Ciencia, Innovación y Universidades (Grant RED2018-102412-T). F.O. is grateful for the contract funded by Junta de Castilla y León, the European Social Fund and the Youth Employment Initiative. J.G.R. thanks Ministerio de Economía y Competitividad for his postdoctoral contract (Grant CTQ2017-83935-R AEI/FEDER, UE).
2021-11-08T12:21:53Z
2021-11-08T12:21:53Z
2020-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
1424-8220
http://hdl.handle.net/10259/6121
10.3390/s20185179
eng
Sensors. 2020, V. 20, n. 18, 5179
https://doi.org/10.3390/s20185179
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-83935-R/ES/ESPECTROELECTROQUIMICA RAMAN CUANTITATIVA
info:eu-repo/grantAgreement/Junta de Castilla y León//BU297P18
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/ RED2018-102412-T/ES/RED DE SENSORES Y BIOSENSORES ELECTROQUIMICOS
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
application/pdf
MDPI