2026-04-21T06:35:21Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/66932022-11-11T12:02:05Zcom_10259_4363com_10259_5086com_10259_2604com_10259_4365col_10259_4364col_10259_4366
Taghizadeh Shool, Maryam
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Amiri Rudbari, Hadi
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600
Gil Antón, Tania
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600
Cuevas Vicario, José Vicente
137
600
0000-0002-2421-1529
García Ruiz, Begoña
217
600
Busto Vázquez, Natalia
83
600
Moini, Nakisa
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Blacque, Olivier
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2022-06-03T09:10:36Z
2022-06-03T09:10:36Z
2022-04
1477-9226
http://hdl.handle.net/10259/6693
10.1039/D2DT00401A
1477-9234
Ru(II) polypyridyl complexes are widely used in biological fields, due to their physico-chemical and photophysical properties. In this paper, a series of new chiral Ru(II) polypyridyl complexes (1–5) with the general formula {Δ/Λ-[Ru(bpy)2(X,Y-sal)]BF4} (bpy = 2,2′-bipyridyl; X,Y-sal = 5-bromosalicylaldehyde (1), 3,5-dibromosalicylaldehyde (2), 5-chlorosalicylaldehyde (3), 3,5-dichlorosalicylaldehyde (4) and 3-bromo-5-chlorosalicylaldehy (5)) were synthesized and characterized by elemental analysis, FT-IR, and 1H/13C NMR spectroscopy. Also, the structures of complexes 1 and 5 were determined by X-ray crystallography; these results showed that the central Ru atom adopts a distorted octahedral coordination sphere with two bpy and one halogen-substituted salicylaldehyde. DFT and TD-DFT calculations have been performed to explain the excited states of these complexes. The singlet states with higher oscillator strength are correlated with the absorption signals and are mainly described as 1MLCT from the ruthenium centre to the bpy ligands. The lowest triplet states (T1) are described as 3MLCT from the ruthenium center to the salicylaldehyde ligand. The theoretical results are in good agreement with the observed unstructured band at around 520 nm for complexes 2, 4 and 5. Biological studies on human cancer cells revealed that dihalogenated ligands endow the Ru(II) complexes with enhanced cytotoxicity compared to monohalogenated ligands. In addition, as far as the type of halogen is concerned, bromine is the halogen that provides the highest cytotoxicity to the synthesized complexes. All complexes induce cell cycle arrest in G0/G1 and apoptosis, but only complexes bearing Br are able to provoke an increase in intracellular ROS levels and mitochondrial dysfunction.
Research Council of the University of Isfahan (Iran) for financial support of this work. Financial support from La Caixa Foundation (LCF/PR/PR12/11070003), Ministerio de Ciencia, Innovación y Universidades (Grant PID2019-111215RB-I00 and RTI2018-102040-B-100) and Consejería de Educación, Junta de Castilla y León, FEDER (BU305P18) is gratefully acknowledged.
application/pdf
eng
Royal Society of Chemistry
Dalton Transactions. 2022, V. 51. n. 19, p. 7658-7672
https://doi.org/10.1039/D2DT00401A
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111215RB-I00/ES/DESARROLLO DE NUEVOS SENSORES QUIMICOS PARA LA DETECCION RAPIDA Y SELECTIVA DE DISPOSITIVOS EXPLOSIVOS IMPROVISADOS
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-102040-B-I00/ES/PROPIEDADES ANTIMICROBIANAS DE NUEVOS COMPLEJOS ORGANOMETALICOS
info:eu-repo/grantAgreement/Junta de Castilla y León//BU305P18/Castilla y León/DISEÑO Y CARACTERIZACIÓN DE COMPLEJOS BIOINORGÁNICOS Y CLÚSTERES CUÁNTICOS ATÓMICOS. PROPIEDADES ANTIMICROBIANAS EN CEPAS RESISTENTES. PROPIEDADES ANTITUMORALES EN LA OSCURIDAD Y BAJO IRRADIACIÓN
info:eu-repo/grantAgreement/Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona//LCF%2FPR%2FPR12%2F11070003
Attribution 3.0 Unported
http://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
Química física
Chemistry, Physical and theoretical
The effect of halogenation of salicylaldehyde on the antiproliferative activities of {Δ/Λ-[Ru(bpy)2(X,Y-sal)]BF4} complexes†
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Dalton Transactions
51
19
7658
7672
THUMBNAIL
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oai:riubu.ubu.es:10259/6693
2022-11-11 13:02:05.512
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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