2026-06-30T01:10:28Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/67772022-07-21T00:05:22Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925

González Saiz, Beatriz Carreira Barral, Israel Pertejo Fernández, Pablo Gómez Ayuso, Javier Quesada Pato, Roberto García Valverde, María Anions Cesium Inorganic carbon compounds Mixtures Solvents The diastereoselective synthesis of two families of pyrrolopiperazine-2,6-diones is presented. These compounds were prepared by one-pot Ugi/nucleophilic substitution/N-acylation/debenzoylation/(elimination) sequences. This novel route provides straightforward access to a wide variety of pyrrolopiperazine-2,6-diones with high chemical yields and complete diastereoselectivities. The proposed synthetic strategy poses a significant improvement compared to the syntheses of pyrrolopiperazine-2,6-diones previously described, as it allows introduction of different substituents to the C4 position and the diastereoselective generation of a new stereogenic center on the bridgehead carbon (C8a). 2022-07-20 2022-07-20 2022-07 info:eu-repo/semantics/article 0022-3263 http://hdl.handle.net/10259/6777 10.1021/acs.joc.2c00694 1520-6904 eng The Journal of Organic Chemistry. 2022, V. 87, n. 14, p. 9391–9398 https://doi.org/10.1021/acs.joc.2c00694 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117610RB-I00/ES/SMALL MOLECULE TRANSMEMBRANE ANION CARRIERS FOR BIOLOGICAL APPLICATIONS info:eu-repo/grantAgreement/Junta de Castilla y León//BU067P20 info:eu-repo/grantAgreement/Junta de Castilla y León//BU075G19 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional American Chemical Society