2026-06-30T04:09:40Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/67772022-07-21T00:05:22Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925

00925njm 22002777a 4500 dc González Saiz, Beatriz author Carreira Barral, Israel author Pertejo Fernández, Pablo author Gómez Ayuso, Javier author Quesada Pato, Roberto author García Valverde, María author 2022-07 The diastereoselective synthesis of two families of pyrrolopiperazine-2,6-diones is presented. These compounds were prepared by one-pot Ugi/nucleophilic substitution/N-acylation/debenzoylation/(elimination) sequences. This novel route provides straightforward access to a wide variety of pyrrolopiperazine-2,6-diones with high chemical yields and complete diastereoselectivities. The proposed synthetic strategy poses a significant improvement compared to the syntheses of pyrrolopiperazine-2,6-diones previously described, as it allows introduction of different substituents to the C4 position and the diastereoselective generation of a new stereogenic center on the bridgehead carbon (C8a). 0022-3263 http://hdl.handle.net/10259/6777 10.1021/acs.joc.2c00694 1520-6904 Anions Cesium Inorganic carbon compounds Mixtures Solvents One-Pot Diastereoselective Synthesis of Pyrrolopiperazine-2,6-diones by a Ugi/Nucleophilic Substitution/N-Acylation Sequence