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<title>The Burden of Carbohydrates in Health and Disease</title>
<creator>Clemente-Suárez, Vicente Javier</creator>
<creator>Mielgo Ayuso, Juan</creator>
<creator>Martín-Rodríguez, Alexandra</creator>
<creator>Ramos-Campo, Domingo Jesús</creator>
<creator>Redondo-Flórez, Laura</creator>
<creator>Tornero-Aguilera, José Francisco</creator>
<subject>Metabolic disease</subject>
<subject>Cancer</subject>
<subject>Gut microbiome</subject>
<subject>Asthma</subject>
<subject>Nutrition</subject>
<subject>Carbohydrates</subject>
<description>Foods high in carbohydrates are an important part of a healthy diet, since they provide&#xd;
the body with glucose to support bodily functions and physical activity. However, the abusive&#xd;
consumption of refined, simple, and low-quality carbohydrates has a direct implication on the&#xd;
physical and mental pathophysiology. Then, carbohydrate consumption is postulated as a crucial&#xd;
factor in the development of the main Western diseases of the 21st century. We conducted this&#xd;
narrative critical review using MedLine (Pubmed), Cochrane (Wiley), Embase, and CinAhl databases&#xd;
with the MeSH-compliant keywords: carbohydrates and evolution, development, phylogenetic,&#xd;
GUT, microbiota, stress, metabolic health, consumption behaviors, metabolic disease, cardiovascular&#xd;
disease, mental disease, anxiety, depression, cancer, chronic kidney failure, allergies, and asthma&#xd;
in order to analyze the impact of carbohydrates on health. Evidence suggests that carbohydrates,&#xd;
especially fiber, are beneficial for the well-being and growth of gut microorganisms and consequently&#xd;
for the host in this symbiotic relationship, producing microbial alterations a negative effect on mental&#xd;
health and different organic systems. In addition, evidence suggests a negative impact of simple&#xd;
carbohydrates and refined carbohydrates on mood categories, including alertness and tiredness,&#xd;
reinforcing a vicious circle. Regarding physical health, sugar intake can affect the development and&#xd;
prognosis of metabolic disease, as an uncontrolled intake of refined carbohydrates puts individuals&#xd;
at risk of developing metabolic syndrome and subsequently developing metabolic disease.</description>
<date>2023-03-21</date>
<date>2023-03-21</date>
<date>2022-09</date>
<type>info:eu-repo/semantics/article</type>
<identifier>http://hdl.handle.net/10259/7573</identifier>
<identifier>10.3390/nu14183809</identifier>
<identifier>2072-6643</identifier>
<language>eng</language>
<relation>Nutrients. 2022, V. 14, n. 18, 3809</relation>
<relation>https://doi.org/10.3390/nu14183809</relation>
<rights>http://creativecommons.org/licenses/by/4.0/</rights>
<rights>info:eu-repo/semantics/openAccess</rights>
<rights>Atribución 4.0 Internacional</rights>
<publisher>MDPI</publisher>
</thesis></metadata></record></GetRecord></OAI-PMH>