2026-04-28T15:33:14Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/75802023-03-23T01:05:29Zcom_10259_6256com_10259_5086com_10259_2604col_10259_6257
Viribay, Aitor
7b865eb2-ebab-456c-adce-a1bbc36563fa
600
Fernández-Landa, Julen
cc0b0941-1dbd-4fb7-8106-5fcc50898bb3
600
Castañeda-Babarro, Arkaitz
45d2e7e5-545b-4c99-ae02-72d5f75a88cb
600
Collado, Pilar S.
3608216a-8d2c-4d97-92c8-a3cf790b2d38
600
Fernández-Lázaro, Diego
16276ee1-055a-40d4-a68f-43a24bde4210
600
Mielgo Ayuso, Juan
627
600
0000-0002-6554-4602
2023-03-22T08:46:35Z
2023-03-22T08:46:35Z
2022-08
http://hdl.handle.net/10259/7580
10.3390/nu14173479
2072-6643
Supplementation with Citrulline (Cit) has been shown to have a positive impact on aerobic
exercise performance and related outcomes such as lactate, oxygen uptake (VO2
) kinetics, and the rate
of perceived exertion (RPE), probably due to its relationship to endogenous nitric oxide production.
However, current research has shown this to be controversial. The main objective of this systematic
review and meta-analysis was to analyze and assess the effects of Cit supplementation on aerobic
exercise performance and related outcomes, as well as to show the most suitable doses and timing
of ingestion. A structured literature search was carried out by the PRISMA® (Preferred Reporting
Items for Systematic Reviews and Meta-Analyses) and PICOS guidelines in the following databases:
Pubmed/Medline, Scopus, and Web of Science (WOS). A total of 10 studies were included in the
analysis, all of which exclusively compared the effects of Cit supplementation with those of a placebo
group on aerobic performance, lactate, VO2
, and the RPE. Those articles that used other supplements
and measured other outcomes were excluded. The meta-analysis was carried out using Hedges’ g
random effects model and pooled standardized mean differences (SMD). The results showed no
positive effects of Cit supplementation on aerobic performance (pooled SMD = 0.15; 95% CI (−0.02 to
0.32); I
2
, 0%; p = 0.08), the RPE (pooled SMD = −0.03; 95% CI (−0.43 to 0.38); I
2
, 49%; p = 0.9), VO2
kinetics (pooled SMD = 0.01; 95% CI (−0.16 to 0.17); I
2
, 0%; p = 0.94), and lactate (pooled SMD = 0.25;
95% CI (−0.10 to 0.59); I
2
, 0%; p = 0.16). In conclusion, Cit supplementation did not prove to have
any benefits for aerobic exercise performance and related outcomes. Where chronic protocols seemed
to show a positive tendency, more studies in the field are needed to better understand the effects.
application/pdf
eng
MDPI
Nutrients. 2022, V. 14, n. 17, 3479
https://doi.org/10.3390/nu14173479
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Citrulline
Ergogenic aids
Physical performance
Nitric oxide
Aerobic
Endurance
Fisiología
Physiology
Effects of Citrulline Supplementation on Different Aerobic Exercise Performance Outcomes: A Systematic Review and Meta-Analysis
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Nutrients
14
17
THUMBNAIL
Viribay-nutrients_2022.pdf.jpg
Viribay-nutrients_2022.pdf.jpg
IM Thumbnail
image/jpeg
3441
https://riubu.ubu.es/bitstream/10259/7580/4/Viribay-nutrients_2022.pdf.jpg
0c0c3c65d7efc2071d5ff65f8df5aaaa
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
999
https://riubu.ubu.es/bitstream/10259/7580/3/license.txt
b295bcbce42e2caabeb0c623d3860c06
MD5
3
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://riubu.ubu.es/bitstream/10259/7580/2/license_rdf
0175ea4a2d4caec4bbcc37e300941108
MD5
2
ORIGINAL
Viribay-nutrients_2022.pdf
Viribay-nutrients_2022.pdf
application/pdf
2722376
https://riubu.ubu.es/bitstream/10259/7580/1/Viribay-nutrients_2022.pdf
6b88b47fa09f9099e79c10ac4267e7dd
MD5
1
10259/7580
oai:riubu.ubu.es:10259/7580
2023-03-23 02:05:29.961
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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