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<title>Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia—A Systematic Review</title>
<creator>Fernández-Araque, Ana</creator>
<creator>Verde, Zoraida</creator>
<creator>Torres-Ortega, Clara</creator>
<creator>Sainz-Gil, María</creator>
<creator>Velasco-González, Verónica</creator>
<creator>González Bernal, Jerónimo</creator>
<creator>Mielgo Ayuso, Juan</creator>
<subject>Antioxidants</subject>
<subject>Fibromyalgia</subject>
<subject>Pain</subject>
<subject>Supplementation</subject>
<subject>Systematic review</subject>
<description>In recent years, antioxidant supplements have become popular to counteract the effects&#xd;
of oxidative stress in fibromyalgia and one of its most distressing symptoms, pain. The aim of&#xd;
this systematic review was to summarize the effects of antioxidant supplementation on pain levels&#xd;
perceived by patients diagnosed with fibromyalgia. The words used respected the medical search&#xd;
terms related to our objective including antioxidants, fibromyalgia, pain, and supplementation.&#xd;
Seventeen relevant articles were identified within Medline (PubMed), Scopus, Web of Science (WOS),&#xd;
the Cochrane Database of Systematic Review, and the Cochrane Central Register of Controlled Trials.&#xd;
This review found that antioxidant supplementation is efficient in reducing pain in nine of the studies&#xd;
reviewed. Studies with a duration of supplementation of at least 6 weeks showed a benefit on pain&#xd;
perception in 80% of the patients included in these studies. The benefits shown by vitamins and&#xd;
coenzyme Q10 are remarkable. Further research is needed to identify the effects of other types of&#xd;
antioxidants, such as extra virgin olive oil and turmeric. More homogeneous interventions in terms&#xd;
of antioxidant doses administered and duration would allow the effects on pain to be addressed more&#xd;
comprehensively.</description>
<date>2023-03-29</date>
<date>2023-03-29</date>
<date>2022-04</date>
<type>info:eu-repo/semantics/article</type>
<identifier>http://hdl.handle.net/10259/7610</identifier>
<identifier>10.3390/jcm11092462</identifier>
<identifier>2077-0383</identifier>
<language>eng</language>
<relation>Journal of Clinical Medicine. 2022, V. 11, n. 9, 2462</relation>
<relation>https://doi.org/10.3390/jcm11092462</relation>
<rights>http://creativecommons.org/licenses/by/4.0/</rights>
<rights>info:eu-repo/semantics/openAccess</rights>
<rights>Atribución 4.0 Internacional</rights>
<publisher>MDPI</publisher>
</thesis></metadata></record></GetRecord></OAI-PMH>