2026-04-28T19:31:22Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/79932023-11-23T12:24:34Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

Aydillo, Teresa 2f7d4618-7bd5-4338-b48a-6f41c2afa835 Escalera, Alba 5463caa4-c12f-43c8-9c71-047f1adf54b3 Strohmeier, Shirin e701b44c-9cf6-48f2-8c7c-a543d9502b72 Aslam, Sadaf 34ce451c-1783-43a0-99fe-d911a3c31bcd Sánchez Céspedes, Javier b66b1253-2795-4136-b8eb-70b10e4b34fe Ayllón Barasoain, Juan 852 600 0000-0002-7556-8106 Roca Oporto, Cristina 35b66169-db90-49e0-aa0e-5c0ec75a927f Pérez Romero, Pilar b27683f8-6edf-44d8-845e-31b5c05550b5 Montejo, Miguel fcd0f85b-f2ba-4543-ac4e-7dfcb2ccfdc8 Gavalda, Joan 0e8f6ab3-10a7-49cf-99a8-e5e27f7ce393 Muñoz, Patricia a25703b2-b43e-4c32-9fd1-96b421fd3d21 López Medrano, Francisco bd441ae6-27ae-4d90-a8cc-62ab6a8cd465 Carratala, Jordi f0df9280-1a50-4411-99d4-afb2e61aab0a Krammer, Florian 134d72a4-c1a0-45c7-97bf-f4dc99569766 García Sastre, Adolfo 9de2ea8b-c019-414d-bb90-b1d51ef5bbd7 Cordero, Elisa b0bed7fe-44b2-430d-9b3f-54bff9749f69 2023-11-10T13:45:57Z 2023-11-10T13:45:57Z 2020 2666-3791 http://hdl.handle.net/10259/7993 10.1016/J.XCRM.2020.100130 Hemagglutination-inhibitory antibodies are usually highly strain specific with little effect on infection with drifted or shifted strains. The significance of broadly cross-reactive non-HAI anti-influenza antibodies against conserved domains of virus glycoproteins, such as the hemagglutinin (HA) stalk, is of great interest. We characterize a cohort of 40 H1N1pmd09 influenza-infected patients and identify lower respiratory symptoms (LRSs) as a predictor for development of pneumonia. A binomial logistic regression of log10 pre-existing antibody values shows that the probability of LRS occurrence decreased with increased anti-HA full-length and stalk antibody ELISA titers. However, a multilevel logistic regression model adjusted by other potential serocorrelates demonstrates that only antibodies directed against the stalk of HA correlate with protection from lower respiratory infection, limiting disease progression. Our predictive model indicates that a threshold of protective immunity based on broadly cross-reactive HA stalk antibodies could be feasible. This work was supported by the Programa de Investigación sobre gripe A/H1N1, Instituto de Salud Carlos III, Ministerio. de Ciencia e Innovación (GR09/0041); the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III, co-financed by the European Development Regional Fund “A way to Achieve Europe” ERDF; the Spanish Network for Research in Infectious Diseases (REIPI RD06/0008 to E.C.); NIAID grants P01AI097092 and U19AI135972; CRIP (Center for Research on Influenza Pathogenesis), an NIAID-funded Center of Excellence on Influenza Research and Surveillance (CEIRS; contract HHSN272201400008C); and SEM-CIVIC, an NIAID-funded Collaborative Influenza Vaccine Innovation Center (contract 75N93019C00051 to A.G.-S. and F.K.). application/pdf eng Cell Press Cell Reports Medicine. 2020, V. 1, n. 8, 100130 https://doi.org/10.1016/j.xcrm.2020.100130 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Influenza antibodies Correlates of protection Transplant patients Viral pneumonia Medicina Microbiología Enfermedades infecciosas Medicine Microbiology Communicable diseases Pre-existing Hemagglutinin Stalk Antibodies Correlate with Protection of Lower Respiratory Symptoms in Flu-Infected Transplant Patients info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cell Reports Medicine 1 8 100130 THUMBNAIL Aydillo-crp_2020.pdf.jpg Aydillo-crp_2020.pdf.jpg IM Thumbnail image/jpeg 3899 https://riubu.ubu.es/bitstream/10259/7993/4/Aydillo-crp_2020.pdf.jpg 5cc366a8cb18860d1258b8ac6d5c08be MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/7993/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/7993/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Aydillo-crp_2020.pdf Aydillo-crp_2020.pdf application/pdf 1785175 https://riubu.ubu.es/bitstream/10259/7993/1/Aydillo-crp_2020.pdf a697f27c0d803b48b95bdd6e037acab2 MD5 1 10259/7993 oai:riubu.ubu.es:10259/7993 2023-11-23 13:24:34.741 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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