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oai:riubu.ubu.es:10259/79942023-11-23T12:24:55Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

Muñoz Moreno, Raquel 6a5f0f32-fbb9-4d5c-a865-06a1786dc766 Martínez Romero, Carles 4f8a8290-2a6e-440b-97fa-12f7e7981a5b Blanco Melo, Daniel 3f1b6a0f-bc04-47fb-b2f6-2ec9881277a1 Forst, Christian V. 003ca68f-9be7-4c17-b714-6df0d5001588 Nachbagauer, Raffael 82324927-4a7b-40f4-a5b8-87a5e7f9a35a Benitez, Asiel Arturo 618aab8f-f29e-43df-aca9-3b5c7438aef8 Mena, Ignacio 5f7d032e-0d94-44b4-bb61-8f941c15b59e Aslam, Sadaf 34ce451c-1783-43a0-99fe-d911a3c31bcd Balasubramaniam, Vinod 449ac160-c3de-4706-84a5-9501e4875b8f Lee, Ilseob c7287738-94bd-4d82-b4b8-3762bd8ebc37 Panis, Maryline 924f8551-232c-4dc1-b68c-efd1eb794da7 Ayllón Barasoain, Juan 852 600 0000-0002-7556-8106 Sachs, David f55a4659-cba0-4654-a9b0-56f36ef2f90d Park, Man-Seong 189ac90a-f46f-425d-91bd-2ff544b517ed Krammer, Florian 134d72a4-c1a0-45c7-97bf-f4dc99569766 tenOever, Benjamin R. 4fe3416c-8a70-402b-95ef-fab15b758379 García Sastre, Adolfo 9de2ea8b-c019-414d-bb90-b1d51ef5bbd7 2023-11-10T13:46:28Z 2023-11-10T13:46:28Z 2019 2211-1247 http://hdl.handle.net/10259/7994 10.1016/j.celrep.2019.11.070 Influenza A viruses (IAVs) have a remarkable tropism in their ability to circulate in both mammalian and avian species. The IAV NS1 protein is a multifunctional virulence factor that inhibits the type I interferon host response through a myriad of mechanisms. How NS1 has evolved to enable this remarkable property across species and its specific impact in the overall replication, pathogenicity, and host preference remain unknown. Here we analyze the NS1 evolutionary landscape and host tropism using a barcoded library of recombinant IAVs. Results show a surprisingly great variety of NS1 phenotypes according to their ability to replicate in different hosts. The IAV NS1 genes appear to have taken diverse and random evolutionary pathways within their multiple phylogenetic lineages. In summary, the high evolutionary plasticity of this viral protein underscores the ability of IAVs to adapt to multiple hosts and aids in our understanding of its global prevalence. This research work was supported partially by CRIP (Center for Research on Influenza Pathogenesis), an NIH-NIAID-funded Center of Excellence for Influenza Research and Surveillance (CEIRS) (contract HHSN272201400008C), and by NIH-NIAID (grants U19AI117873 and U19AI135972). This research was also supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF), funded by the Ministry of Science and ICT of the Republic of Korea (NRF-2018M3A9H4056537 to M.-S.P., PI). application/pdf eng Cell Press Cell Reports. 2019, V. 29, n. 12, p. 3997-4009.e5 https://doi.org/10.1016/j.celrep.2019.11.070 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Influenza virus Orthomyxovirus NS1 evolution IFN response Innate immunity Barcoded library Medicina Salud Microbiología Genética Enfermedades infecciosas Medicine Health Microbiology Genetics Communicable diseases Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cell Reports 29 12 3997 4009.e5 THUMBNAIL Muñoz-cr_2019.pdf.jpg Muñoz-cr_2019.pdf.jpg IM Thumbnail image/jpeg 4403 https://riubu.ubu.es/bitstream/10259/7994/4/Mu%c3%b1oz-cr_2019.pdf.jpg 62dd0081c729013647c262c332962653 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/7994/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/7994/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Muñoz-cr_2019.pdf Muñoz-cr_2019.pdf application/pdf 5908865 https://riubu.ubu.es/bitstream/10259/7994/1/Mu%c3%b1oz-cr_2019.pdf eaf4364d38b4ce00499ed8e2a3aafdfc MD5 1 10259/7994 oai:riubu.ubu.es:10259/7994 2023-11-23 13:24:55.674 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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