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oai:riubu.ubu.es:10259/79952023-11-23T12:25:10Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

Ayllón Barasoain, Juan 852 600 0000-0002-7556-8106 Domingues, Patricia 192967b5-4e17-42a5-9db4-3754c151c4b5 Rajsbaum, Ricardo 0cf7967e-233d-4bf0-b44d-acd237723f48 Miorin, Lisa 059f762f-4d32-4718-a378-689c1914c061 Schmolke, Mirco cf2e0308-ea5c-40d9-b6f7-e29b18b4251a Hale, Benjamin G. acc3bd63-b78d-4900-a8fb-06b2d01623cf García Sastre, Adolfo 9de2ea8b-c019-414d-bb90-b1d51ef5bbd7 600 2023-11-13T08:05:36Z 2023-11-13T08:05:36Z 2014 0022-538X http://hdl.handle.net/10259/7995 10.1128/JVI.01567-14 1098-5514 Although an effective interferon antagonist in human and avian cells, the novel H7N9 influenza virus NS1 protein is defective at inhibiting CPSF30. An I106M substitution in H7N9 NS1 can restore CPSF30 binding together with the ability to block host gene expression. Furthermore, a recombinant virus expressing H7N9 NS1-I106M replicates to higher titers in vivo, and is subtly more virulent, than the parental virus. Natural polymorphisms in H7N9 NS1 that enhance CPSF30 binding may be cause for concern. This work was partially supported by U.S. NIH funding to A.G.-S. (under grants R01AI046954 and U19AI083025 and CRIP [Center for Research on Influenza Pathogenesis, an NIAID Center of Excellence for Influenza Research and Surveillance {CEIRS}] contract HHSN266200700010C) and funding from the Medical Research Council, United Kingdom, and the European Commission (FP7 Marie Curie CIG 321703: UBIFLU) (both to B.G.H.). B.G.H. is a Sir Henry Dale Fellow jointly funded by the Wellcome Trust and the Royal Society (grant number 100034/Z/12/Z). application/pdf eng American Society for Microbiology Journal of Virology. 2014, V. 88, n. 20, p. 12146-12151 https://doi.org/10.1128/jvi.01567-14 Attribution 3.0 Unported http://creativecommons.org/licenses/by/3.0/ info:eu-repo/semantics/openAccess Medicina Microbiología Salud Enfermedades infecciosas Medicine Microbiology Health Communicable diseases A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Journal of Virology 88 20 12146 12151 THUMBNAIL Ayllon-jov_2014.pdf.jpg Ayllon-jov_2014.pdf.jpg IM Thumbnail image/jpeg 4642 https://riubu.ubu.es/bitstream/10259/7995/4/Ayllon-jov_2014.pdf.jpg b6221825a7999741215fdf323fc77a64 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/7995/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/7995/2/license_rdf f9a6a4096bf314846151c97900b2090d MD5 2 ORIGINAL Ayllon-jov_2014.pdf Ayllon-jov_2014.pdf application/pdf 936290 https://riubu.ubu.es/bitstream/10259/7995/1/Ayllon-jov_2014.pdf 27dede02d8894a48a02310758d8cfede MD5 1 10259/7995 oai:riubu.ubu.es:10259/7995 2023-11-23 13:25:10.976 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es RWwgYXV0b3IgY29tbyDDum5pY28gdGl0dWxhciBkZSBsb3MgZGVyZWNob3MgZGUgcHJvcGllZGFkIGludGVsZWN0dWFsIGRlIGxhIG9icmEsIG8gZGlzcG9uaWVuZG8gZGUgbG9zIGRlYmlkb3MgcGVybWlzb3MgZGUgbG9zIG90cm9zIHRpdHVsYXJlcywgc2kgbG9zIGh1YmllcmEsIHkgZW4gdmlydHVkIGRlIGxvcyBkZXJlY2hvcyBxdWUgbGUgY29uZmllcmUgbGEgbGVnaXNsYWNpw7NuIHZpZ2VudGUgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIHkgZGVyZWNob3MgZGUgYXV0b3IsIA0KQVVUT1JJWkEgYSBsYSBVbml2ZXJzaWRhZCBkZSBCdXJnb3MgYSBkaWZ1bmRpciwgZGUgbWFuZXJhIGdyYXR1aXRhLCBlbCBjb250ZW5pZG8gZGUgbG9zIGFyY2hpdm9zIGRpZ2l0YWxlcyBxdWUgY29ycmVzcG9uZGVuIGFsIGRvY3VtZW50byBkZXNjcml0byBhbnRlcmlvcm1lbnRlLCBjb24gY2Fyw6FjdGVyIG5vIGV4Y2x1c2l2byB5IGRlIG1hbmVyYSBww7pibGljYSBlbiBhY2Nlc28gYWJpZXJ0byBhIHRyYXbDqXMgZGUgSW50ZXJuZXQsIHBhcmEgbG8gcXVlIGxhIEJpYmxpb3RlY2EgcHJvY2VkZXLDoSBhIGFyY2hpdmFybG9zIGVuIGVsIFJlcG9zaXRvcmlvIEluc3RpdHVjaW9uYWwuIEFzaW1pc21vIGF1dG9yaXphIGEgbGEgVW5pdmVyc2lkYWQgZGUgQnVyZ29zIGEgcmVhbGl6YXIgbGFzIHRyYW5zZm9ybWFjaW9uZXMgbmVjZXNhcmlhcyBkZSBmb3JtYXRvLCBubyBkZSBjb250ZW5pZG8sIHBhcmEgZ2FyYW50aXphciBsYSBwcmVzZXJ2YWNpw7NuIHkgZWwgYWNjZXNvIGVuIGVsIGZ1dHVyby4NCg0KRWwgYXV0b3IgZGlzcG9uZSwgZW4gdG9kbyBjYXNvLCBkZWwgZGVyZWNobyBhIHJldm9jYXIgZXN0YSBhdXRvcml6YWNpw7NuLg0KDQpMYSBjZXNpw7NuIGRlIGRlcmVjaG9zIGRlIGVzdGEgb2JyYSBzZSBlbmN1ZW50cmEgc3VqZXRhIGEgbGEgbGVnaXNsYWNpw7NuIHZpZ2VudGUgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIHkgZGVyZWNob3MgZGUgYXV0b3Iu