2026-04-28T02:28:25Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/80512023-11-18T01:05:26Zcom_10259_5827com_10259_5086com_10259_2604col_10259_5828
Biomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birth
Cavia Saiz, Mónica
Arnaez, Juan
Cilla, Amaia
Puente, Laura
García-Miralles, Laura C.
Muñiz Rodríguez, Pilar
Oxidative stress
Infant
Birth
Cord blood
Glutathione
Malondialdehyde
Carbonyl
Creatinine
Alimentos
Biología molecular
Bioquímica
Food
Molecular biology
Biochemistry
The clinical relevance of stress biomarkers in newborns is well established. Currently,
oxidative stress (OS) parameters are seen to play an important role in neonatal resuscitation guidelines,
and a link has been observed between the amount of oxygen delivered and the level of OS and the
development of various pathologies. The aim of the current study was to investigate changes in
neonatal plasma and urine OS status during the first hours after birth. A lower antioxidant capacity
(TAC) and higher levels of malondialdehyde in blood were observed in newborns at the time of
birth compared with results 48 h postnatally. The urine revealed a significant and progressive
increase in TAC and creatinine during the first 36 h of life, with a progressive decline thereafter.
Meanwhile, malondialdehyde in urine samples showed no significant differences over time. Overall,
the correlation between blood and urine parameters was poor, except for the relationship between
umbilical vein glutathione reduced/oxidized ratio and urine malondialdehyde (r = 0.7; p = 0.004)
and between TAC in the umbilical artery and urine (r = −0.547; p = 0.013). The biomarkers evaluated
in this study could be established as reference values for neonatal OS.
This research was funded by Fundación Burgos por la Investigación de la Salud (grant number 1088) and Gerencia Regional de Castilla y Leon (grant number GRS 1773/A/18).
2023-11-17T13:20:22Z
2023-11-17T13:20:22Z
2023-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://hdl.handle.net/10259/8051
10.3390/antiox12061249
2076-3921
eng
Antioxidants. 2023, V. 12, n. 6, 1249
https://doi.org/10.3390/antiox12061249
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
application/pdf
MDPI