2026-04-27T20:45:29Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/80512023-11-18T01:05:26Zcom_10259_5827com_10259_5086com_10259_2604col_10259_5828

Cavia Saiz, Mónica 116 600 0000-0001-5132-381X Arnaez, Juan d89bfd1f-ce6b-47e6-9ad2-dbb7090ff517 600 Cilla, Amaia 56fea09d-e0c1-49f3-9c1f-0dd537c8d5f4 600 Puente, Laura ade5d61a-46c9-4f4e-bc87-d1bb8a9802ea 600 García-Miralles, Laura C. eb7fa73d-902c-4e91-a841-922adf48f2c0 600 Muñiz Rodríguez, Pilar 380 600 0000-0002-9306-0082 2023-11-17T13:20:22Z 2023-11-17T13:20:22Z 2023-06 http://hdl.handle.net/10259/8051 10.3390/antiox12061249 2076-3921 The clinical relevance of stress biomarkers in newborns is well established. Currently, oxidative stress (OS) parameters are seen to play an important role in neonatal resuscitation guidelines, and a link has been observed between the amount of oxygen delivered and the level of OS and the development of various pathologies. The aim of the current study was to investigate changes in neonatal plasma and urine OS status during the first hours after birth. A lower antioxidant capacity (TAC) and higher levels of malondialdehyde in blood were observed in newborns at the time of birth compared with results 48 h postnatally. The urine revealed a significant and progressive increase in TAC and creatinine during the first 36 h of life, with a progressive decline thereafter. Meanwhile, malondialdehyde in urine samples showed no significant differences over time. Overall, the correlation between blood and urine parameters was poor, except for the relationship between umbilical vein glutathione reduced/oxidized ratio and urine malondialdehyde (r = 0.7; p = 0.004) and between TAC in the umbilical artery and urine (r = −0.547; p = 0.013). The biomarkers evaluated in this study could be established as reference values for neonatal OS. This research was funded by Fundación Burgos por la Investigación de la Salud (grant number 1088) and Gerencia Regional de Castilla y Leon (grant number GRS 1773/A/18). application/pdf eng MDPI Antioxidants. 2023, V. 12, n. 6, 1249 https://doi.org/10.3390/antiox12061249 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Oxidative stress Infant Birth Cord blood Glutathione Malondialdehyde Carbonyl Creatinine Alimentos Biología molecular Bioquímica Food Molecular biology Biochemistry Biomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birth info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Antioxidants 12 6 THUMBNAIL Cavia-antioxidants_2023.pdf.jpg Cavia-antioxidants_2023.pdf.jpg IM Thumbnail image/jpeg 3366 https://riubu.ubu.es/bitstream/10259/8051/4/Cavia-antioxidants_2023.pdf.jpg 5ba681baef0b1881f697fc6be98ad349 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8051/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/8051/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Cavia-antioxidants_2023.pdf Cavia-antioxidants_2023.pdf application/pdf 610546 https://riubu.ubu.es/bitstream/10259/8051/1/Cavia-antioxidants_2023.pdf 37e6c62018e2640699ea66b387658cda MD5 1 10259/8051 oai:riubu.ubu.es:10259/8051 2023-11-18 02:05:26.519 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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