2026-06-30T04:09:37Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/80702023-11-22T01:05:27Zcom_10259_5827com_10259_5086com_10259_2604col_10259_5828

00925njm 22002777a 4500 dc Gerardi, Gisela author Cavia Saiz, Mónica author Muñiz Rodríguez, Pilar author 2022 The wine pomace is the main winery by-products that suppose an economic and environmental problem and their use as a functional ingredient are being increasingly recognized as a good and inexpensive source of bioactive compounds. In this sense, it is known the potential health properties of wine pomace products in the prevention of disorders associated with oxidative stress and inflammation such as endothelial dysfunction, hypertension, hyperglycemia, diabetes, obesity. Those effects are due to the bioactive compounds of wine pomace and the mechanisms concern especially modulation of antioxidant/prooxidant activity, improvement of nitric oxide bioavailability, reduction of pro-inflammatory cytokines and modulation of antioxidant/inflammatory signal pathways. This review mainly summarizes the mechanisms of wine pomace products as modulators of oxidative status involved in cell pathologies as well as their potential therapeutic use for cardiovascular diseases. For this purpose, the review provides an overview of the findings related to the wine pomace bioactive compounds profile, their bioavailability and the action mechanisms for maintaining the redox cell balance involved in health benefits. The review suggests an important role for wine pomace product in cardiovascular diseases prevention and their regular food intake may attenuate the development and progression of comorbidities associated with cardiovascular diseases. 1040-8398 http://hdl.handle.net/10259/8070 10.1080/10408398.2021.1914542 1549-7852 Polyphenols Fiber Bioactive compounds Wine by-products Cardiovascular health Signaling pathways Oxidative stress Wine pomace From winery by-product to healthy product: bioavailability, redox signaling and oxidative stress modulation by wine pomace product