2026-05-11T19:33:51Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/80702023-11-22T01:05:27Zcom_10259_5827com_10259_5086com_10259_2604col_10259_5828

Gerardi, Gisela 229 600 0000-0003-2510-0422 Cavia Saiz, Mónica 116 600 0000-0001-5132-381X Muñiz Rodríguez, Pilar 380 600 0000-0002-9306-0082 2023-11-21T08:13:08Z 2023-11-21T08:13:08Z 2022 1040-8398 http://hdl.handle.net/10259/8070 10.1080/10408398.2021.1914542 1549-7852 The wine pomace is the main winery by-products that suppose an economic and environmental problem and their use as a functional ingredient are being increasingly recognized as a good and inexpensive source of bioactive compounds. In this sense, it is known the potential health properties of wine pomace products in the prevention of disorders associated with oxidative stress and inflammation such as endothelial dysfunction, hypertension, hyperglycemia, diabetes, obesity. Those effects are due to the bioactive compounds of wine pomace and the mechanisms concern especially modulation of antioxidant/prooxidant activity, improvement of nitric oxide bioavailability, reduction of pro-inflammatory cytokines and modulation of antioxidant/inflammatory signal pathways. This review mainly summarizes the mechanisms of wine pomace products as modulators of oxidative status involved in cell pathologies as well as their potential therapeutic use for cardiovascular diseases. For this purpose, the review provides an overview of the findings related to the wine pomace bioactive compounds profile, their bioavailability and the action mechanisms for maintaining the redox cell balance involved in health benefits. The review suggests an important role for wine pomace product in cardiovascular diseases prevention and their regular food intake may attenuate the development and progression of comorbidities associated with cardiovascular diseases. The authors thank the financial support of the Spain Ministry of Science, Innovation and Universities (Ref. PGC2018-097113-B-I00). application/pdf eng Taylor & Francis Critical Reviews in Food Science and Nutrition. 2022, V. 62, n. 27, p. 7427-7448 https://doi.org/10.1080/10408398.2021.1914542 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-097113-B-I00/ES/APLICACION DE INGREDIENTES FUNCIONALES OBTENIDOS DE SUBPRODUCTOS DE VINIFICACION PARA MEJORAR LA SEGURIDAD ALIMENTARIA, VIDA UTIL Y PROPIEDADES SALUDABLES DE PRODUCTOS DE AVE/ Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Polyphenols Fiber Bioactive compounds Wine by-products Cardiovascular health Signaling pathways Oxidative stress Wine pomace Alimentos Bioquímica Biología molecular Food Biochemistry Molecular biology From winery by-product to healthy product: bioavailability, redox signaling and oxidative stress modulation by wine pomace product info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Critical Reviews in Food Science and Nutrition 62 27 7427 7448 THUMBNAIL Gerardi_crfsn_2022.pdf.jpg Gerardi_crfsn_2022.pdf.jpg IM Thumbnail image/jpeg 3623 https://riubu.ubu.es/bitstream/10259/8070/4/Gerardi_crfsn_2022.pdf.jpg d6cceed5bbefacb047b812b4929fbf62 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8070/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 914 https://riubu.ubu.es/bitstream/10259/8070/2/license_rdf 24013099e9e6abb1575dc6ce0855efd5 MD5 2 ORIGINAL Gerardi_crfsn_2022.pdf Gerardi_crfsn_2022.pdf application/pdf 1162930 https://riubu.ubu.es/bitstream/10259/8070/1/Gerardi_crfsn_2022.pdf 9f6ca8d38bc26e984ca1a9f894236548 MD5 1 10259/8070 oai:riubu.ubu.es:10259/8070 2023-11-22 02:05:27.395 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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