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oai:riubu.ubu.es:10259/82732024-01-10T01:05:27Zcom_10259_6229com_10259_4534com_10259.4_106com_10259_2604col_10259_8272

Parameter fitting in models of biofilm resistance to antibiotics Cebrián de Barrio, Elena Carpio, Ana Microbiología Microbiology Matemáticas Mathematics Biofilms are communities formed by bacteria attached to surfaces and protected from antibiotic attacks by a polymeric matrix (EPS). Dynamic Energy Budget (DEB) models take into account the diversity of the mechanisms involved in biofilm resistance to antibiotics and allow us to study their effects on bacteria. These models involve sets of unknown parameters, which must be fitted to experimental data in such a way that the model predictions are consistent with experiments. Varying these parameters in a simplified model, we are able to calibrate their values and understand their influence on different bacterial distributions. Research partially supported by MINECO grant No. MTM2014-56948-C2-1-P. 2024-01-09T14:04:48Z 2024-01-09T14:04:48Z 2018 info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion 0094-243X http://hdl.handle.net/10259/8273 10.1063/1.5043956 1551-7616 eng AIP Conference Proceedings. 2018, V. 1978, 350003 https://doi.org/10.1063/1.5043956 info:eu-repo/semantics/openAccess application/pdf American Institute of Physics