2026-04-19T06:29:42Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/84102024-05-10T11:36:33Zcom_10259_4734com_10259_5086com_10259_2604com_10259_4415com_10259_3989com_10259.4_106com_10259_5645col_10259_4735col_10259_4416col_10259_5646

00925njm 22002777a 4500 dc Sáiz Vázquez, Olalla author Gracia García, Patricia author Ubillos Landa, Silvia author Puente Martínez, Alicia author Casado Yusta, Silvia author Olaya, Beatriz author Santabárbara, Javier author 2021-04 Alzheimer’s disease (AD) is the most frequent cause of dementia, linked to morbidity and mortality among elderly patients. Recently, several clinical studies suggested that depression is a potential risk factor for cognitive decline and AD. A review of meta-analyses was performed, calculating pooled odds ratios to estimate the risk of AD in people with a prior diagnosis (or clinically significant symptoms) of depression. A total of six meta-analyses which represented 28 individual studies were analyzed. A significant association between depression and AD was found (OR = 1.54, 95% CI [1.02–2.31]; p = 0.038). The results showed that heterogeneity across studies was substantial. We found a significant positive effect size for clinical measures of depression, but not for symptomatic rating scales, in the association of depression with risk of AD. The type of rating scale used to assess depression and the cut-off criteria selected also moderated the relationship between depression and AD risk. We found that studies that used clinically significant criteria for diagnosis of depression had more consistent and significant results than studies that used symptomatic scales. http://hdl.handle.net/10259/8410 10.3390/jcm10091809 2077-0383 Depression Alzheimer's disease Clinical and symptomatic criteria Meta-meta-analysis Depression as a Risk Factor for Alzheimer’s Disease: A Systematic Review of Longitudinal Meta-Analyses