2026-04-28T04:47:19Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/85612025-01-22T10:17:59Zcom_10259_9895com_10259_3989com_10259.4_106com_10259_2604col_10259_9896

Abreu, Ana Cristina df67f7d0-0ba2-4a6d-ae99-02045ca20fad Morales Navas, Miguel 872 500 0000-0001-7222-2743 Pérez Fernández, Cristian 41151d83-48a8-4363-a23a-b2cf33d3d481 Sánchez Santed, Fernando 3945434c-d67b-4d35-8c6d-262ce027f039 Fernández, Ignacio c9508272-9af3-4d9d-925b-8c7cbbfd513f 600 2024-02-02T12:45:43Z 2024-02-02T12:45:43Z 2021 1554-8929 http://hdl.handle.net/10259/8561 10.1021/ACSCHEMBIO.1C00053 1554-8937 NMR offers the unique potential to holistically screen hundreds of metabolites and has already proved to be a powerful technique able to provide a global picture of a wide range of metabolic processes underlying complex and multifactorial diseases, such as neurodegenerative and neurodevelopmental diseases. The aim of this study was to apply an NMR-based metabolomics approach to explore brain metabolic changes in both male and female rats induced by prenatal exposure to two chemicals associated with autism disorders—the organophosphorus pesticide chlorpyrifos (CPF) and the antiepileptic drug valproic acid (VPA)—at different postnatal ages. Depending on the age and on the brain region (hippocampus and cerebellum), several metabolites were shown to be significantly affected by exposure to both compounds. The evaluation of the spectral profiles revealed that the nervous-system-specific metabolite N-acetylaspartate (NAA), amino acid neurotransmitters (e.g., glutamate, glutamine, GABA, glycine), pyroglutamic acid, unsaturated fatty acids, and choline-based compounds are discriminant biomarkers. Additionally, metabolic changes varied as a function of age, but importantly not of sex. This research has been funded by the by the State Research Agency (projects RTC-2016-5239-2, CTQ2017-84334-R, and PSI2017-86847-C2-1-R) of the Spanish Ministry of Science, Innovation and Universities and EU FEDER funds. A.C.A. thanks University of Almería for a postdoctoral Hipatia fellowship. application/pdf eng American Chemical Society ACS Chemical Biology. 2021, V. 16, n. 4, p. 753-765 https://doi.org/10.1021/ACSCHEMBIO.1C00053 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Fisiología Química física Psicología Salud Physiology Chemistry, Physical and theoretical Psychology Health NMR-Based Metabolomics Approach to Explore Brain Metabolic Changes Induced by Prenatal Exposure to Autism-Inducing Chemicals info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ACS Chemical Biology 16 4 753 765 THUMBNAIL Abreu-acscb_2021.pdf.jpg Abreu-acscb_2021.pdf.jpg IM Thumbnail image/jpeg 5405 https://riubu.ubu.es/bitstream/10259/8561/4/Abreu-acscb_2021.pdf.jpg 18640f9e0ca87eedcaa5f60ae511d1ae MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8561/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/8561/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Abreu-acscb_2021.pdf Abreu-acscb_2021.pdf application/pdf 3298822 https://riubu.ubu.es/bitstream/10259/8561/1/Abreu-acscb_2021.pdf 88467b693912dede39e34b05763f47e1 MD5 1 10259/8561 oai:riubu.ubu.es:10259/8561 2025-01-22 11:17:59.016 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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