2026-06-29T19:59:14Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/85632025-01-22T10:17:06Zcom_10259_9895com_10259_3989com_10259.4_106com_10259_2604col_10259_9896

Pérez Fernández, Cristian Morales Navas, Miguel Guardia Escote, Laia Colomina, María Teresa Giménez, Estela Sánchez Santed, Fernando 2024-02-02T13:02:14Z 2024-02-02T13:02:14Z 2021 0161-813X http://hdl.handle.net/10259/8563 10.1016/j.neuro.2021.07.002 1872-9711 The molecular and behavioral effects of the developmental exposure to low doses of Chlorpyrifos (CPF) have been intensively studied in young (neonates and adolescents), and adult animals. However, no study examined influences of developmental CPF exposure in older adult or geriatric rats. This is relevant as such ages are generally linked to cognitive decline and the onset of specific neurodegenerative disorders, some of them previously associated with CPF exposure in both preclinical and human studies. 1 mg/kg/mL of CPF was orally administered to both male and female Wistar rats from Postnatal day 10 to 15. Animals’ spatial memory, learning, compulsivity, motricity, and anxiety were analyzed with Morris Water Maze (15–16 months of age) and the Plus-maze (at 18 months of age). Results showed that postnatal CPF exposure did not alter either spatial memory, compulsive-like behaviors, or anxiety levels in late-adult rats. However, CPF exposed rats were hyposensitive to brief disruptions (Probe stage) following the learning phase and showed a general decrease in locomotor activity in both paradigms. These data are relevant as it is the first time that developmental exposure to CPF has been studied at such a late age, observing important effects in locomotor activity that could be linked to specific pathologies previously associated with CPF effects in people. Future studies should extend these findings to other behaviors and molecular outcomes. This study was supported by two grants from the Ministerio de Economía y Competitividad, Spanish Government and the Fondo Europeo de Desarrollo Regional (MINECOFEDER). Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER and PSI2017-86847-C2-2-R. application/pdf eng Elsevier Neurotoxicology. 2021, V. 86, p. 69-77 https://doi.org/10.1016/j.neuro.2021.07.002 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Organophosphates Chlorpyrifos Spatial memory Compulsivity Anxiety Old age Fisiología Química física Psicología Salud Physiology Chemistry, Physical and theoretical Psychology Health Pesticides and aging: Preweaning exposure to Chlorpyrifos induces a general hypomotricity state in late-adult rats info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Neurotoxicology 86 69 77