2026-06-29T20:14:22Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/85632025-01-22T10:17:06Zcom_10259_9895com_10259_3989com_10259.4_106com_10259_2604col_10259_9896

00925njm 22002777a 4500 dc Pérez Fernández, Cristian author Morales Navas, Miguel author Guardia Escote, Laia author Colomina, María Teresa author Giménez, Estela author Sánchez Santed, Fernando author 2021 The molecular and behavioral effects of the developmental exposure to low doses of Chlorpyrifos (CPF) have been intensively studied in young (neonates and adolescents), and adult animals. However, no study examined influences of developmental CPF exposure in older adult or geriatric rats. This is relevant as such ages are generally linked to cognitive decline and the onset of specific neurodegenerative disorders, some of them previously associated with CPF exposure in both preclinical and human studies. 1 mg/kg/mL of CPF was orally administered to both male and female Wistar rats from Postnatal day 10 to 15. Animals’ spatial memory, learning, compulsivity, motricity, and anxiety were analyzed with Morris Water Maze (15–16 months of age) and the Plus-maze (at 18 months of age). Results showed that postnatal CPF exposure did not alter either spatial memory, compulsive-like behaviors, or anxiety levels in late-adult rats. However, CPF exposed rats were hyposensitive to brief disruptions (Probe stage) following the learning phase and showed a general decrease in locomotor activity in both paradigms. These data are relevant as it is the first time that developmental exposure to CPF has been studied at such a late age, observing important effects in locomotor activity that could be linked to specific pathologies previously associated with CPF effects in people. Future studies should extend these findings to other behaviors and molecular outcomes. 0161-813X http://hdl.handle.net/10259/8563 10.1016/j.neuro.2021.07.002 1872-9711 Organophosphates Chlorpyrifos Spatial memory Compulsivity Anxiety Old age Pesticides and aging: Preweaning exposure to Chlorpyrifos induces a general hypomotricity state in late-adult rats