2026-04-28T11:35:11Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/86092024-02-08T01:05:34Zcom_10259_3592com_10259_3591com_10259.4_106com_10259_2604com_10259_3924com_10259_5086col_10259_3930col_10259_3925
Repositorio Institucional de la Universidad de Burgos
author
Alonso Carrillo, Daniel
author
Carreira Barral, Israel
author
Mielczarek, Marcin
author
Sancho Medina, Andrea
author
Herran, Enara
author
Vairo, Claudia
author
Pozo, Ángel del
author
Luzuriaga, Iris
author
Lazcanoiturburu, Nerea
author
Ibarrola, Oihane
author
Ponce, Sara
author
Villar Vidal, María
author
García Valverde, María
author
Quesada Pato, Roberto
2024-02-07T08:07:42Z
2024-02-07T08:07:42Z
2023-08
1477-0520
http://hdl.handle.net/10259/8609
10.1039/D3OB01182H
1477-0539
Six novel click-tambjamines (1–6) bearing an alkyl chain of varying length linked to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) to evaluate their transmembrane anion transport activity both when free (i.e., not encapsulated) and nanoformulated. Nanostructured lipid carriers (NLCs) are an example of drug delivery systems (DDSs) that stand out because of their versatility. In this work we show that NLCs can be used to efficiently formulate highly lipophilic anionophores and experiments conducted in model liposomes reveal that these formulations are adequate to deliver anionophores without compromising their transport activity. This result paves the way to facilitate the study of highly lipophilic anionophores and their potential use as future drugs.
eng
Attribution-NonCommercial 3.0 Unported
Formulation and evaluation of anion transporters in nanostructured lipid carriers
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/8609/1/Alonso_rsc_2023.pdf
File
MD5
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application/pdf
Alonso_rsc_2023.pdf