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oai:riubu.ubu.es:10259/86332025-01-23T01:05:22Zcom_10259_9895com_10259_3989com_10259.4_106com_10259_2604col_10259_9896

Pérez Fernández, Cristian 41151d83-48a8-4363-a23a-b2cf33d3d481 600 Morales Navas, Miguel 872 500 0000-0001-7222-2743 Aguilera Sáez, Luis Manuel dd3745f2-fe36-491e-aeae-018dd3eaf860 600 Abreu, Ana Cristina df67f7d0-0ba2-4a6d-ae99-02045ca20fad 600 Guardia Escote, Laia c642b9b9-7d83-4118-b8c5-f018fa660d79 600 Fernández, Ignacio c9508272-9af3-4d9d-925b-8c7cbbfd513f 600 Garrido Cárdenas, José Antonio fcd94710-d219-4c38-9d4a-242c7ad1f982 600 Colomina, María Teresa b33a2d2e-b902-4a99-809f-551a9af83d1c 600 Giménez, Estela ef5db8db-2f1a-4c20-a3c1-c79a073c5b22 600 Sánchez Santed, Fernando 3945434c-d67b-4d35-8c6d-262ce027f039 600 2024-02-08T11:39:42Z 2024-02-08T11:39:42Z 2020-05 0013-9351 http://hdl.handle.net/10259/8633 10.1016/j.envres.2020.109341 Autism spectrum disorder (ASD) is a complex neurodevelopmental pathology characterized by altered verbalizations, reduced social interaction behavior, and stereotypies. Environmental factors have been associated with its development. Some researchers have focused on pesticide exposure. Chlorpyrifos (CPF) is the most used Organophosphate. Previous developmental studies with CPF showed decreased, enhanced or no effect on social outcomes eminently in mice. The study of CPF exposure during preweaning stages on social behavior is sparse in mice and non-existent in rats. d stressors could be at the basis of ASD development, and around postnatal day 10 in the rat is equivalent to the human birthday in neurodevelopmental terms. We explored the effects of exposure to low doses (1mg/kg/mL/day) of CPF during this stage regarding: sociability, dominance gut microbiome and plasma metabolomic profile, since alterations in these systems have also been linked to ASD. There was a modest influence of CPF on social behavior in adulthood, with null effects during adolescence. Dominance and hierarchical status were not affected by exposure. Dominance status explained the significant reduction in reaction to social novelty observed on the sociability test. CPF induced a significant gut microbiome dysbiosis and triggered a hyperlipidemic, hypoglycemic/hypogluconeogenesis and a general altered cell energy production in females. These behavioral results in rats extend and complement previous studies with mice and show novel influences on gut metagenomics and plasma lipid profile and metabolomics, but do not stablish a relation between the exposure to CPF and the ASD phenotype. The effects of dominance status on reaction to social novelty have an important methodological meaning for future research on sociability. This study was supported by two grants from the Ministerio de Economía y Competitividad, Spanish Government and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER). Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER and PSI2017-86847-C2-2-R. application/pdf eng Elsevier Environmental Research. 2020, V. 184, 109341 https://doi.org/10.1016/j.envres.2020.109341 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Chlorpyrifos Development ASD Sociability Dominance Gut microbiota Metabolomics Evidence of approval (animals) Fisiología Biología molecular Psychology Molecular biology Medium and long-term effects of low doses of Chlorpyrifos during the postnatal, preweaning developmental stage on sociability, dominance, gut microbiota and plasma metabolites info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Environmental Research 184 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/8633/5/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 5 THUMBNAIL Perez-er_2020.pdf.jpg Perez-er_2020.pdf.jpg IM Thumbnail image/jpeg 3477 https://riubu.ubu.es/bitstream/10259/8633/3/Perez-er_2020.pdf.jpg a101cddb541eedb1444be3066750bddf MD5 3 Perez-Environmental_r_2020.pdf.jpg Perez-Environmental_r_2020.pdf.jpg IM Thumbnail image/jpeg 3964 https://riubu.ubu.es/bitstream/10259/8633/6/Perez-Environmental_r_2020.pdf.jpg c4fdc3808570492fc95f31ea013f9331 MD5 6 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8633/2/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 2 ORIGINAL Perez-Environmental_r_2020.pdf Perez-Environmental_r_2020.pdf application/pdf 785089 https://riubu.ubu.es/bitstream/10259/8633/4/Perez-Environmental_r_2020.pdf fd39294205253b95a763e96613a73d0e MD5 4 10259/8633 oai:riubu.ubu.es:10259/8633 2025-01-23 02:05:22.254 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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