2026-04-28T18:55:11Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/87752024-03-08T01:05:25Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Jiménez Jiménez, Félix Javier 02f5f100-7fe5-479b-928c-82c10d8af362 600 García Martín, Elena 44ac8f01-77eb-47ef-aa34-aad0863fd584 600 Alonso Navarro, Hortensia a641a32b-b4f5-4149-9f6b-7005b1434b65 600 Martínez, Carmen ae317123-a563-4b50-a605-d883dc4e80dc 600 Zurdo, Martín 91e27121-dd7d-4594-95e5-43f82472e885 600 Turpín Fenoll, Laura 912b443a-7369-47df-b0bc-0f7a16bc6563 600 Millán Pascual, Jorge 5e268e19-e3c7-4937-bada-a38c4c04fc92 600 Adeva Bartolomé, Teresa 2505c7c2-bf93-431a-b769-d242fb5f0b6e 600 Cubo Delgado, Esther 131 600 0000-0003-0018-1182 Navacerrada, Francisco 0b4137c7-a26f-42fd-a28d-5148980318f4 600 Rojo Sebastián, Ana 907fce62-edbc-4b18-8bf0-fa88164fb887 600 Rubio, Lluisa fc7eaeb4-a849-4c2a-9f04-0abb28091caf 600 Ortega Cubero, Sara 563a3adf-8fdb-40d2-811a-12911858a784 600 Pastor, Pau ff71ed4b-9f41-494e-bf23-661c26564083 600 Calleja, Marisol 4d110fda-b914-4666-b4fa-ea616a4e54e9 600 Plaza Nieto, José Francisco 34234f75-7a20-4a26-bf23-3fd992863d3d 600 Pilo de la Fuente, Belén fbfc533d-c178-4def-af98-9452257902dc 600 Arroyo Solera, Margarita 2801a43a-cb80-4279-9414-11313bd05be5 600 García Albea, Esteban 420af694-9491-4f11-afd2-dc7a2c084a2f 600 Agúndez, José A. G. b70ab1ce-ce60-490e-befc-ca20c4431ff7 600 2024-03-07T12:20:31Z 2024-03-07T12:20:31Z 2015-11 0025-7974 http://hdl.handle.net/10259/8775 10.1097/MD.0000000000002125 Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS. We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay. The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively). Restless legs syndrome patients carrying the allelic variant rs731236G had an earlier age at onset, and those carrying the rs731236GG genotype had higher severity of RLS, although these data disappeared after multivariate analyses. None of the SNPs studied was related with the positivity of family history of RLS. These results suggest a modest, but significant association between VDR rs731236 SNP and the risk for RLS. This work was supported in part by Grants PI12/00241, PI12/00324, and RETICS RD12/0013/0002 from Fondo de Investigacio´n Sanitaria, Instituto de Salud Carlos III, Madrid, Spain, and GR15026 from Junta de Extremadura, Me´rida, Spain, and PRIS10016 (Fundesalud, Me´rida,Spain), and by grants from the Spanish Ministry of Science and Innovation SAF2006-10126 (2006–2009) and SAF2010-22329-C02-01 (2011- 2013) to PP and by the ‘‘Unio´n Te´cnica de Empresas’’ (UTE) project FIMA to PP and project from the Centro de Investigaciones Me´dicas Aplicadas (CIMA), Spain. Partially funded with FEDER funds. application/pdf eng Wolters Kluwer Health Medicine. 2014, V. 94, n. 47, e2125 https://journals.lww.com/md-journal/fulltext/2015/11240/association_between_vitamin_d_receptor_rs731236.57.aspx Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Sistema nervioso-Enfermedades Medicina Nervous system-Diseases Medicine Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Medicine 94 47 THUMBNAIL Jimenez-medicine_2014.pdf.jpg Jimenez-medicine_2014.pdf.jpg IM Thumbnail image/jpeg 3807 https://riubu.ubu.es/bitstream/10259/8775/4/Jimenez-medicine_2014.pdf.jpg bc62f27d272a241684f9b273307c4fdc MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8775/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/8775/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Jimenez-medicine_2014.pdf Jimenez-medicine_2014.pdf application/pdf 194427 https://riubu.ubu.es/bitstream/10259/8775/1/Jimenez-medicine_2014.pdf 6d61824bbedf3261cb960be4d0589bec MD5 1 10259/8775 oai:riubu.ubu.es:10259/8775 2024-03-08 02:05:25.554 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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