2026-04-28T17:56:01Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/87782024-03-09T01:05:26Zcom_10259_4244com_10259_5086com_10259_2604col_10259_4245
Repositorio Institucional de la Universidad de Burgos
author
Trigueros Andrés, Ester
author
Benito Román, Oscar
author
Oliveira, Andreia P.
author
Videira, Romeu A.
author
Andrade, Paula B.
author
Sanz Díez, Mª Teresa
author
Beltrán Calvo, Sagrario
2024-03-08T08:01:31Z
2024-03-08T08:01:31Z
2024-02
2076-3921
http://hdl.handle.net/10259/8778
10.3390/antiox13020205
2076-3921
Onion skin waste (OSW), the primary non-edible byproduct from onion processing, offers a renewable source of bioactive compounds. This study aims to valorize OSW through subcritical water extraction (SWE), aligning with a circular economy and biorefinery principles. SWE was carried out at 145 °C and 50 bar for 50 min in a discontinuous reactor, producing a phenolic-rich extract (32.3 ± 2.6 mg/g) dominated by protocatechuic acid (20.3 ± 2.5 mg/g), quercetin-4′-O-glucoside (7.5 ± 0.2 mg/g), and quercetin (3.2 ± 0.6 mg/g). Additionally, the extract contains sugars (207.1 ± 20.3 mg sucrose-Eq/g), proteins (22.8 ± 1.6 mg BSA-Eq/g), and free amino acids (20.4 ± 1.2 mg arginine-Eq/g). Its phenolic richness determines its scavenging activity against ●NO and O2●− radicals and its α-glucosidase and aldose-reductase inhibition without affecting α-amylase. Notably, the extract demonstrates significant α-glucosidase inhibition (IC50 = 75.6 ± 43.5 µg/mL), surpassing acarbose (IC50 = 129.5 ± 1.0 µg/mL) in both pure enzyme and cell culture tests without showing cytotoxicity to AGS, HepG2, and Caco-2 human cell lines. The extract’s bioactivity and nutritional content make it suitable for developing antioxidant and antidiabetic nutraceutical/food components, highlighting SWE’s potential for OSW valorization without using organic solvents.
eng
Atribución 4.0 Internacional
Hydrothermal treatment
Onion waste
Polyphenols
Quercetin
Antioxidant activity
Antidiabetic potential
Onion (Allium cepa L.) Skin Waste Valorization: Unveiling the Phenolic Profile and Biological Potential for the Creation of Bioactive Agents through Subcritical Water Extraction
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/8778/1/Trigueros-Antioxidants_2024.pdf
File
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application/pdf
Trigueros-Antioxidants_2024.pdf