2026-06-01T09:19:11Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/87802024-03-09T01:05:25Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Ayala, Alba d9a348ca-7832-439c-9f71-f90023922aa0 600 Triviño Juárez, José Matías 919efd10-3b5e-4c7f-89d3-b554207b7660 600 Forjaz, María Joao ccb9d876-6a7e-4785-bcf4-18540dea22fc 600 Rodríguez Blázquez, Carmen 50d1a7cd-cc1e-48f8-a861-55a738fba9ba 600 Rojo Abuin, José Manuel 98bfa78b-c199-46b2-b5e0-676f31c31993 600 Martínez Martín, Pablo 3b256da2-afa7-4d7d-91e0-61436565bbac 600 Cubo Delgado, Esther 131 600 0000-0003-0018-1182 ELEP Group 7036616b-286d-4e22-b9ab-60fecbb958c5 600 2024-03-08T08:57:26Z 2024-03-08T08:57:26Z 2017-10 http://hdl.handle.net/10259/8780 10.3389/fneur.2017.00551 1664-2295 Objective: The aim of this study is to present a predictive model of Parkinson’s disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD). Methods: This is an observational, longitudinal study with annual follow-up assessments over 3 years (four time points). A multilevel analysis and multiple imputation techniques were performed to generate a predictive model that estimates changes in the CISI-PD at 1, 2, and 3 years. Results: The clinical state of patients (CISI-PD) significantly worsened in the 3-year follow-up. However, this change was of small magnitude (effect size: 0.44). The following baseline variables were significant predictors of the global severity change: baseline global severity of disease, levodopa equivalent dose, depression and anxiety symptoms, autonomic dysfunction, and cognitive state. The goodness-of-fit of the model was adequate, and the sensitive analysis showed that the data imputation method applied was suitable. Conclusion: Disease progression depends more on the individual’s baseline characteristics than on the 3-year time period. Results may contribute to a better understanding of the evolution of PD including the non-motor manifestations of the disease. The Spanish Longitudinal PD Patient Study (Estudio longitudinal de pacientes con enfermedad de Parkinson) was supported by an Intramural Research Programme grant from the Carlos III Institute of Health (Code: EPY1271/05). Partial funding was also obtained from the following grants: ENVACES (MINECO/FEDER/UE, ref. CSO2015-64115-R) and ENCAGE-CM (Comunidad de Madrid, ref. S2015/HUM-3367). application/pdf eng Frontiers Media Frontiers in Neurology. 2017, V. 8 https://doi.org/10.3389/fneur.2017.00551 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Parkinson’s disease Disease global severity Predictive model Multilevel analysis Multiple imputation Sistema nervioso-Enfermedades Neurología Medicina Nervous system-Diseases Neurology Medicine Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Frontiers in Neurology 8 THUMBNAIL Ayala-fn_2017.pdf.jpg Ayala-fn_2017.pdf.jpg IM Thumbnail image/jpeg 3424 https://riubu.ubu.es/bitstream/10259/8780/4/Ayala-fn_2017.pdf.jpg ceb5cb378d8968f3b91295a4aa08d539 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8780/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/8780/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Ayala-fn_2017.pdf Ayala-fn_2017.pdf application/pdf 460159 https://riubu.ubu.es/bitstream/10259/8780/1/Ayala-fn_2017.pdf 1eb521cf5f23af71b94735731f0fc877 MD5 1 10259/8780 oai:riubu.ubu.es:10259/8780 2024-03-09 02:05:25.832 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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