2026-04-29T12:09:28Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/87872024-03-09T01:05:22Zcom_10259_6688com_10259_5086com_10259_2604com_10259_4219col_10259_6689col_10259_4220

Cubo Delgado, Esther 131 600 0000-0003-0018-1182 Gallego Nieto, César d1fe9e1a-92f9-4b23-94d8-d5851d96d70d 600 Elizari Roncal, Miren acb263fa-bbb2-4083-a9ef-92a3b2aa8fe0 600 Barroso Pérez, Mª Teresa da9197e0-e38a-4bd6-aa95-f2256ba5a629 600 Collazo Riobó, Carla 623 600 0000-0002-4365-3138 Delgado López, Pedro David bb4ffb05-46f1-4c3d-9b8c-291ab1e32b34 600 2024-03-08T12:47:10Z 2024-03-08T12:47:10Z 2019-07 http://hdl.handle.net/10259/8787 10.5334/tohm.508 2160-8288 Artículo de revisión Background: Restless legs syndrome (RLS) is a common sleep disorder,. although controversial, growing evidence relates the presence of RLS to an increased risk of mortality, mainly due to cardiovascular events. The aim of this article was to review the role of RLS as a risk factor of mortality according to independent cohort studies. Methods: We performed a literature review via PubMed database for articles relating RLS and mortality. We used the random-effects model to calculate the pooled effect estimates on mortality. Heterogeneity between studies was assessed using quantitative and qualitative analysis. Results: Out of 100 articles identified, 13 were finally included. Although studies were heterogeneous (p = 0.001), no significant publication bias was found. When all cohort studies were considered, the random-effects model yielded a significantly increased risk of mortality in RLS versus non-RLS patients (13 studies, hazard ratio [HR] = 1.52, 95% confidence interval [CI] 1.28–1.80). However, this association was not statistically significant when only cohort studies using the international RLS diagnostic criteria were considered (5 studies, HR = 1.63, 95% CI 0.94–2.81). Discussion: The results of this meta-analysis suggest that RLS seems to be a risk factor of mortality, although this association is conditioned by the diagnostic criteria used in the studies. Future long-term follow-up standardized mortality studies are needed to address this important question that carries potential impact on population global health. This work was supported by a grant from the Castilla y Leon Health Department (GRS 1764/A/18). application/pdf eng Ubiquity Press Tremor and Other Hyperkinetic Movements. 2019, V. 9 https://tremorjournal.org/articles/10.5334/tohm.508 Attribution-NonCommercial-NoDerivs 3.0 Unported http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Restless legs syndrome Mortality Survival Epidemiology Cohorts Sleep disorder Sistema nervioso-Enfermedades Neurología Medicina Nervous system-Diseases Neurology Medicine Is Restless Legs Syndrome Associated with an Increased Risk of Mortality? A Meta-Analysis of Cohort Studies info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Tremor and Other Hyperkinetic Movements 9 THUMBNAIL Cubo-tohm_2019.pdf.jpg Cubo-tohm_2019.pdf.jpg IM Thumbnail image/jpeg 3836 https://riubu.ubu.es/bitstream/10259/8787/4/Cubo-tohm_2019.pdf.jpg 66701f0bd004ca5590754dfb9638bf04 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8787/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/8787/2/license_rdf c25aca2c744d1595337d59fd646768ec MD5 2 ORIGINAL Cubo-tohm_2019.pdf Cubo-tohm_2019.pdf application/pdf 1216760 https://riubu.ubu.es/bitstream/10259/8787/1/Cubo-tohm_2019.pdf dff053e806ada7557d39277a9b6d7121 MD5 1 10259/8787 oai:riubu.ubu.es:10259/8787 2024-03-09 02:05:22.858 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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