2026-06-01T08:50:54Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/87932024-03-12T01:05:26Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Jesús, Silvia 94414864-0f62-4f22-8d66-e96af70069dd 600 Labrador Espinosa, Miguel A. b9186195-b2fa-495e-9bbe-0b1d376895fe 600 Adarmes Gómez, Astrid D. e201b43e-1629-4879-a266-5c5961bef23f 600 Méndel del Barrio, C. 872e8763-3f8b-4c62-93aa-3a2f5c0dce25 600 Martínez Castrillo, Juan Carlos 6979aa01-2e50-45aa-8e6d-601542f14eef 600 Alonso Cánovas, Araceli 11084725-d00c-4801-8c49-eea09415b862 600 Sánchez Alonso, Pilar 3c44dc0f-518b-4ab1-b1a3-6a857d653e29 600 Novo Pontes, Sabela d6b0f000-126f-4504-9559-f03558fc20f9 600 Alonso Losada, María Gema aa797cfa-68df-4808-90fa-8eb05dfb8fbc 600 López Ariztegui, Nuria 296a85f8-6cd9-43ff-b2f6-8c7a0ba2295b 600 Segundo Rodríguez, José Clemente 7c86ee08-2796-4535-a57a-13b6b02c1046 600 Morales, M. I. b7b78ebf-7a35-488c-a64f-2afd1711bbc6 600 Gastón, Itziar f63aa3b9-5088-4d49-b482-576de9607d97 600 Lacruz Bescos, F. 90fe1019-bf68-464e-b650-09b1a567ee0c 600 Clavero Ibarra, Pedro 3c1bef15-1777-4645-ae52-3a0b30ea6ce1 600 Kulisevsky Bojarsky, Jaume d2206d09-2cc7-4278-8c83-8daf501d594c 600 Pagonabarraga, Javier 4e340c4b-78df-4dca-bd93-4720eba4fbe8 600 Pascual Sedano, Berta 93e5ed5b-4ce3-4041-a8f8-4a7a2bc82006 600 Martínez Martín, Pablo 3b256da2-afa7-4d7d-91e0-61436565bbac 600 Santos García, Diego 57cc455d-4967-4813-bba9-1c5ea287eb86 600 Mir, Pablo 4bc9807f-c2b2-4fa1-a87c-966fcf6b8f12 600 Cubo Delgado, Esther 131 600 0000-0003-0018-1182 COPPADIS Study Group 939e521a-fb6f-43ac-8b9f-b5515f53a388 600 2024-03-11T10:34:07Z 2024-03-11T10:34:07Z 2020-10 http://hdl.handle.net/10259/8793 10.1038/s41598-020-73756-z 2045-2322 The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose. application/pdf eng Springer Nature Scientific Reports. 2020, V. 10, n. 1 https://doi.org/10.1038/s41598-020-73756-z Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Scientific Reports 10 1 THUMBNAIL Jesus-sr_2020.pdf.jpg Jesus-sr_2020.pdf.jpg IM Thumbnail image/jpeg 4756 https://riubu.ubu.es/bitstream/10259/8793/4/Jesus-sr_2020.pdf.jpg 25a82f2814427786d76ae1e9ef650610 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8793/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/8793/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Jesus-sr_2020.pdf Jesus-sr_2020.pdf application/pdf 1405184 https://riubu.ubu.es/bitstream/10259/8793/1/Jesus-sr_2020.pdf 4ba76e5a0eadf9a2e250b4232d984ccf MD5 1 10259/8793 oai:riubu.ubu.es:10259/8793 2024-03-12 02:05:26.638 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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