2026-06-01T08:50:52Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88042024-03-14T11:12:23Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
Santos García, Diego
57cc455d-4967-4813-bba9-1c5ea287eb86
600
Deus-Fonticoba, Teresa de
241ee298-45b9-4d5e-a34e-f3083ef0783c
600
Cores Bartolomé, Carlos
9b5e6b7c-ac5d-40e7-98d8-b9845d29da23
600
Naya Ríos, Lucía
01a0effc-023e-4dec-898f-357161a79ecf
600
García Roca, Lucía
e17d5fc9-2af7-4c59-aeee-1eaa35102f8d
600
Martínez Miró, Cristina
58e322c3-e6e5-4ddb-9f70-4e11d52fd9d3
600
Canfield, Héctor
124f4ea4-2059-41be-9e73-73feeac887b5
600
Jesús, Silvia
94414864-0f62-4f22-8d66-e96af70069dd
600
Aguilar, Miquel
a2b4e910-3b2d-4b27-bff1-411f0efbb3ed
600
Pastor, Pau
ff71ed4b-9f41-494e-bf23-661c26564083
600
Cosgaya, Marina
2f66f5ce-1753-448d-836d-4f018398b6fa
600
García Caldentey, Juan
018fd724-d355-4464-9fd6-8b2123a540b5
600
Caballol, Núria
264549f6-e1d7-42b3-a4f6-696fb90b42f0
600
Legarda, Inés
eb1e95ce-6a7b-49ae-b69f-9af9bbae8417
600
Hernández Vara, Jorge
562507f5-0a69-479c-ae9b-7c57a69a4aa5
600
Cabo López, Iria
5a3c1be8-1c41-4687-9cb0-cf1874284ede
600
López Manzanares, Lydia
3e221eec-a9b4-41e3-86fd-fe4dae6e5307
600
González Aramburu, Isabel
73cdc52d-8eb7-41d0-9f6e-898136822390
600
Ávila Rivera, María A.
ae1d959d-cd86-4cd6-9a50-ffdd3eaee72a
600
Gómez Mayordomo, Víctor
85c8863b-b0ce-477e-b2ea-dbd37cbfbe1b
600
Nogueira, Víctor
70821c60-b9c4-45ec-a4f2-b7d972c23a09
600
Puente, Víctor
a99a68d7-7362-4046-9561-0bc60158afce
600
Dotor, Julio
5618dab6-87cb-4aa6-8661-2589b4f496b6
600
Borrue, Carmen
293bd583-7502-47d8-9d61-0eb87eb60694
600
Solano Vila, Berta
1fe84e64-c454-4054-b91d-860a9da567ca
600
Álvarez Saúco, María
30efeb28-24da-4c71-951c-4585a9ab000e
600
Vela Desojo, Lydia
1e6a5059-3ea0-4183-9bc6-2c6aba340406
600
Escalante Arroyo, Sonia
e4fb3df0-19aa-41bd-9264-1358e79a22c2
600
Cubo Delgado, Esther
131
600
0000-0003-0018-1182
Carrillo Padilla, Francisco
8ac6c575-2ef8-436e-b7dc-51834ece076a
600
Martínez Castrillo, Juan Carlos
6979aa01-2e50-45aa-8e6d-601542f14eef
600
Sánchez Alonso, Pilar
3c44dc0f-518b-4ab1-b1a3-6a857d653e29
600
Alonso Losada, María Gema
aa797cfa-68df-4808-90fa-8eb05dfb8fbc
600
López Ariztegui, Nuria
296a85f8-6cd9-43ff-b2f6-8c7a0ba2295b
600
Gastón, Itziar
f63aa3b9-5088-4d49-b482-576de9607d97
600
Kulisevsky Bojarsky, Jaume
d2206d09-2cc7-4278-8c83-8daf501d594c
600
Blázquez Estrada, Marta
46d3ff25-591b-41f3-bde3-ea1cc7d118c9
600
Seijo, Manuel
459a2988-9c1e-46cf-82d7-d70b0184110d
600
Ruíz Martínez, Javier
d1a8cf9d-a541-4cfd-8097-177abecd2ca5
600
Valero, Caridad
2c523f62-c344-4bed-bdb6-51f83c86ec31
600
Kurtis, Mónica M.
3d523ac0-4505-4c6d-b6a5-1dcb51dac967
600
Fabregues, Oriol de
02f1ccaf-f81e-45d0-be90-7aa1fcfe281a
600
González Ardura, Jessica
5bff2682-a94d-4fac-92cf-809b653fa82e
600
Alonso Redondo, Rubén
c748cfef-65bc-4832-b7f5-d11f74ce23bd
600
Ordás Bandera, Carlos Manuel
7381c907-dbd6-48cf-83e4-3630ebcad0cd
600
López Díaz, Luis M.
7b4dea40-9560-41e9-adfc-44cfc79f1b6e
600
McAfee, Darrian
108a6079-a31f-418a-84ba-ba664c420b5c
600
Martínez Martín, Pablo
3b256da2-afa7-4d7d-91e0-61436565bbac
600
Mir, Pablo
4bc9807f-c2b2-4fa1-a87c-966fcf6b8f12
600
COPPADIS Study Group
939e521a-fb6f-43ac-8b9f-b5515f53a388
600
2024-03-12T10:25:47Z
2024-03-12T10:25:47Z
2021-09
http://hdl.handle.net/10259/8804
10.3390/diagnostics11101801
2075-4418
Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p < 0.0001; Cohen’s effect size = −0.519) was observed but not in controls (N = 124; from 98.87 ± 6.52 to 99.52 ± 2.15; p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p < 0.0001) and BDI-II (OR = 1.080; p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p < 0.0001) and VAFS-Mental (OR = 1.177; p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.
application/pdf
eng
MDPI
Diagnostics. 2021, V. 11, n. 10, 1801
https://doi.org/10.3390/diagnostics11101801
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Activities of Daily Living
Dependency
Disability
Gait
Parkinson’s disease
Sistema nervioso-Enfermedades
Medicina
Neurología
Nervous system-Diseases
Medicine
Neurology
Predictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Diagnostics
11
10
THUMBNAIL
Santos-diagnostics_2021.pdf.jpg
Santos-diagnostics_2021.pdf.jpg
IM Thumbnail
image/jpeg
3835
https://riubu.ubu.es/bitstream/10259/8804/4/Santos-diagnostics_2021.pdf.jpg
e42bd7c74675868cc4e7e2a23c990471
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
999
https://riubu.ubu.es/bitstream/10259/8804/3/license.txt
b295bcbce42e2caabeb0c623d3860c06
MD5
3
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://riubu.ubu.es/bitstream/10259/8804/2/license_rdf
0175ea4a2d4caec4bbcc37e300941108
MD5
2
ORIGINAL
Santos-diagnostics_2021.pdf
Santos-diagnostics_2021.pdf
application/pdf
1382898
https://riubu.ubu.es/bitstream/10259/8804/1/Santos-diagnostics_2021.pdf
8d1ee5ec47408c612e72dcddd19a2be6
MD5
1
10259/8804
oai:riubu.ubu.es:10259/8804
2024-03-14 12:12:23.135
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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