2026-06-01T09:19:45Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88092024-03-13T01:05:29Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease Martínez-Horta, Saul Berj-Kasem, Helena Horta-Barba, Andrea Pascual Sedano, Berta Santos García, Diego Deus-Fonticoba, Teresa de Jesús, Silvia Aguilar, Miquel Planellás, Lluis L. García Caldentey, Juan Caballol, Núria Vives Pastor, Bárbara Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Catalán, María José López Díaz, Luis M. Puente, Víctor García Moreno, José Manuel Borrue, Carmen Solano Vila, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Blázquez Estrada, Marta Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. Fabregues, Oriol de González Ardura, Jessica Prieto Jurczynska, Cristina Martínez Martín, Pablo Mir, Pablo Kulisevsky Bojarsky, Jaume COPPADIS Study Group Parkinson’s disease PD-MCI Cognition Lifestyle Coppadis Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑ bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26). The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patients while no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑ ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation (<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05), and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005). Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially 2024-03-12T12:19:24Z 2024-03-12T12:19:24Z 2021-12 info:eu-repo/semantics/article http://hdl.handle.net/10259/8809 10.1186/s12883-021-02485-1 1471-2377 eng BMC Neurology. 2021, V. 21, n. 1 https://doi.org/10.1186/s12883-021-02485-1 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional Springer Nature