2026-06-01T08:50:53Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88112024-03-13T01:05:27Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
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Cores Bartolomé, Carlos
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García Roca, Lucía
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Martínez Miró, Cristina
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Canfield, Héctor
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Ávila Rivera, María A.
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Gómez Mayordomo, Víctor
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Nogueira, Víctor
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Puente, Víctor
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Dotor, Julio
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Borrue, Carmen
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Fabregues, Oriol de
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González Ardura, Jessica
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Alonso Redondo, Rubén
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Ordás Bandera, Carlos Manuel
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López Díaz, Luis M.
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McAfee, Darrian
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Martínez Martín, Pablo
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Mir, Pablo
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2024-03-12T13:10:09Z
2024-03-12T13:10:09Z
2021-12
http://hdl.handle.net/10259/8811
10.3390/diagnostics11122380
2075-4418
Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity.
application/pdf
eng
MDPI
Diagnostics. 2021, V. 11, n. 2, 2380
https://doi.org/10.3390/diagnostics11122380
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Changes
Motor
Parkinson’s disease
Phenotype
PIGD
Tremor
Sistema nervioso-Enfermedades
Medicina
Neurología
Nervous system-Diseases
Medicine
Neurology
Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
Diagnostics
11
12
THUMBNAIL
Santos-diagnostics__2021.pdf.jpg
Santos-diagnostics__2021.pdf.jpg
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LICENSE
license.txt
license.txt
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ORIGINAL
Santos-diagnostics__2021.pdf
Santos-diagnostics__2021.pdf
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10259/8811
oai:riubu.ubu.es:10259/8811
2024-03-13 02:05:27.319
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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