2026-06-01T08:50:52Zhttps://riubu.ubu.es/oai/request
oai:riubu.ubu.es:10259/88202024-03-15T01:05:13Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
Kovács, Norbert 149d8665-cabe-4e26-8309-242f580acc9c 600 Bergmann, Lars 39398a25-ebc2-4008-b8c7-be0c8426ad38 600 Anca-Herschkovitsch, Marieta e1a4479e-6471-49b3-92d2-17279109f9d7 600 Cubo Delgado, Esther 131 600 0000-0003-0018-1182 Davis, Thomas L. e3f0ce6d-083c-4b71-a06a-59a170e7e077 600 Iansek, Robert c3e67ffe-d7fd-4cc4-8e0b-713fd18e398a 600 Siddiqui, Mustafa S. 1ac8fffa-db1e-4ee2-8a6d-0461cd702bcc 600 Simu, Mihaela c804cd12-7b9d-499a-823a-f929b9eb69f2 600 Standaert, David G. 6da922f3-858b-4e9f-9899-3e00594a5650 600 Chaudhuri, K. Ray 9c6dffc7-c13f-407e-b690-89052e59d909 600 Bourgeois, Paul b487d6bc-0f84-4b8f-818a-2240c88e3a5f 600 Gao, Tianming ce18f0ae-cdcc-4f47-9fb0-a7aba8e747df 600 Kukreja, Pavnit 310f6280-4048-40e8-a3ad-51110ca1805b 600 Pontieri, Francesco E. 0e19bd2c-02a2-4948-84bf-c05c0f7c94c8 600 Aldred, Jason 3efc0f48-3958-4907-ae8f-c3b0f11b415f 600 2024-03-14T11:01:55Z 2024-03-14T11:01:55Z 2022-04 1877-7171 http://hdl.handle.net/10259/8820 10.3233/JPD-212979 1877-718X Background: It is believed that motor symptoms, including dyskinesia, and non-motor symptoms impact health-related quality of life (HRQoL) in patients with Parkinson’s disease (PD), and that improvements in these metrics are correlated. Objective: Investigate the relationship between HRQoL and measures of PD severity and treatment efficacy, including motor and non-motor symptoms. Methods: This was a planned investigation of an international, prospective, single-arm, post-marketing observational study of the long-term effectiveness of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Pearson correlation coefficients (PCC) were calculated for baseline and change from baseline at 12 months between HRQoL and motor and non-motor symptoms. Results: A total of 195 patients were included. At baseline, HRQoL was moderately positively correlated with Activities of Daily Living (UPDRS II, PCC = 0.44), non-motor symptoms (0.48), and measures of sleep (0.50 and 0.40); all p < 0.001. After 12 months of treatment with LCIG, improvements in HRQoL were moderately positively correlated with improvement from baseline in non-motor symptoms (PCC = 0.42), sleep (0.54), and daytime sleepiness (0.40; all p < 0.001), and weakly correlated with improvement in dyskinesia signs and symptoms (PCC = 0.23; p = 0.011). Improvement in HRQoL was not correlated with improvements in OFF time or dyskinesia time. Conclusion: Both at baseline and for change from baseline at 12 months, HRQoL was correlated with baseline and change from baseline in dyskinesia, Activities of Daily Living, and non-motor symptoms, including sleep; but not with baseline or change in OFF time. eng IOS Press Journal of Parkinson's Disease. 2022, V. 12, n. 3, p. 917-926 https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd212979 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Dyskinesia Health-related quality of life Levodopa-carbidopa intestinal gel Non-motor symptoms Parkinson’s disease Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology Outcomes Impacting Quality of Life in Advanced Parkinson’s Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Journal of Parkinson's Disease 12 3 917 926 THUMBNAIL Kovacs-jpd_2022.pdf.jpg Kovacs-jpd_2022.pdf.jpg IM Thumbnail image/jpeg 3220 https://riubu.ubu.es/bitstream/10259/8820/4/Kovacs-jpd_2022.pdf.jpg 6c538f8823569b1917facb95f8ae4ed3 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/8820/3/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/8820/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Kovacs-jpd_2022.pdf Kovacs-jpd_2022.pdf application/pdf 1042741 https://riubu.ubu.es/bitstream/10259/8820/1/Kovacs-jpd_2022.pdf 265df3f1bd2622bcb05898cbcb45780c MD5 1 10259/8820 oai:riubu.ubu.es:10259/8820 2024-03-15 02:05:13.799 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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