2026-06-01T08:54:12Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88222024-03-15T01:05:27Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
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Ordás Bandera, Carlos Manuel
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López Díaz, Luis M.
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Mir, Pablo
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COPPADIS Study Group
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2024-03-14T11:48:47Z
2024-03-14T11:48:47Z
2022-05
http://hdl.handle.net/10259/8822
10.3390/diagnostics12051147
2075-4418
Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score ≥ 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 ± 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 ± 36.48 vs. 34.3 ± 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 ± 37.37) compared to those who did not develop MF (+6.2 ± 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (β = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up.
The study was conducted according to the guidelines of the Declaration of Helsinki, and ap-proved by Comité de Ética de la Investigación Clínica de Galicia from Spain (2014/534; 2/DEC/2014).
application/pdf
eng
MDPI
Diagnostics. 2022, V. 12, n. 5, 1147
https://doi.org/10.3390/diagnostics12051147
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Burden
Follow-up
Non-motor symptoms
Motor fluctuations
Parkinson’s disease
Sistema nervioso-Enfermedades
Medicina
Neurología
Nervous system-Diseases
Medicine
Neurology
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Diagnostics
12
5
THUMBNAIL
Santos-diagnostics_2022.pdf.jpg
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ORIGINAL
Santos-diagnostics_2022.pdf
Santos-diagnostics_2022.pdf
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https://riubu.ubu.es/bitstream/10259/8822/1/Santos-diagnostics_2022.pdf
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10259/8822
oai:riubu.ubu.es:10259/8822
2024-03-15 02:05:27.721
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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