2026-06-01T08:22:58Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88262024-03-15T01:05:28Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Santos García, Diego 57cc455d-4967-4813-bba9-1c5ea287eb86 600 Deus-Fonticoba, Teresa de 241ee298-45b9-4d5e-a34e-f3083ef0783c 600 Cores Bartolomé, Carlos 9b5e6b7c-ac5d-40e7-98d8-b9845d29da23 600 Feal Painceiras, María db92b7b5-d3e7-4c23-ba15-12087bf7e0a5 600 Íñiguez Alvarado, María Cristina 216beac8-ca05-42e0-b700-fb22a314a24f 600 García Díaz, Iago 07c2b62a-a147-49f4-bcbb-050bd9236db4 600 Jesús, Silvia 94414864-0f62-4f22-8d66-e96af70069dd 600 Buongiorno, María Teresa 5475728e-1750-4ac1-826f-40de68bac212 600 Planellás, Lluis L. 22ff4e0b-75de-4a8b-82dc-b64f22675be2 600 Cosgaya, Marina 2f66f5ce-1753-448d-836d-4f018398b6fa 600 García Caldentey, Juan 018fd724-d355-4464-9fd6-8b2123a540b5 600 Caballol, Núria 264549f6-e1d7-42b3-a4f6-696fb90b42f0 600 Legarda, Inés eb1e95ce-6a7b-49ae-b69f-9af9bbae8417 600 Hernández Vara, Jorge 562507f5-0a69-479c-ae9b-7c57a69a4aa5 600 Cabo López, Iria 5a3c1be8-1c41-4687-9cb0-cf1874284ede 600 López Manzanares, Lydia 3e221eec-a9b4-41e3-86fd-fe4dae6e5307 600 González Aramburu, Isabel 73cdc52d-8eb7-41d0-9f6e-898136822390 600 Ávila Rivera, María A. ae1d959d-cd86-4cd6-9a50-ffdd3eaee72a 600 Gómez Mayordomo, Víctor 85c8863b-b0ce-477e-b2ea-dbd37cbfbe1b 600 Nogueira, Víctor 70821c60-b9c4-45ec-a4f2-b7d972c23a09 600 Puente, Víctor a99a68d7-7362-4046-9561-0bc60158afce 600 Dotor, Julio 5618dab6-87cb-4aa6-8661-2589b4f496b6 600 Borrue, Carmen 293bd583-7502-47d8-9d61-0eb87eb60694 600 Solano Vila, Berta 1fe84e64-c454-4054-b91d-860a9da567ca 600 Álvarez Saúco, María 30efeb28-24da-4c71-951c-4585a9ab000e 600 Vela Desojo, Lydia 1e6a5059-3ea0-4183-9bc6-2c6aba340406 600 Escalante Arroyo, Sonia e4fb3df0-19aa-41bd-9264-1358e79a22c2 600 Cubo Delgado, Esther 131 600 0000-0003-0018-1182 Carrillo Padilla, Francisco 8ac6c575-2ef8-436e-b7dc-51834ece076a 600 Martínez Castrillo, Juan Carlos 6979aa01-2e50-45aa-8e6d-601542f14eef 600 Sánchez Alonso, Pilar 3c44dc0f-518b-4ab1-b1a3-6a857d653e29 600 Alonso Losada, María Gema aa797cfa-68df-4808-90fa-8eb05dfb8fbc 600 López Ariztegui, Nuria 296a85f8-6cd9-43ff-b2f6-8c7a0ba2295b 600 Gastón, Itziar f63aa3b9-5088-4d49-b482-576de9607d97 600 Kulisevsky Bojarsky, Jaume d2206d09-2cc7-4278-8c83-8daf501d594c 600 Menéndez González, Manuel 03ba235e-6b96-4bec-bcf7-7bf69c5c144f 600 Seijo, Manuel 459a2988-9c1e-46cf-82d7-d70b0184110d 600 Ruíz Martínez, Javier d1a8cf9d-a541-4cfd-8097-177abecd2ca5 600 Valero, Caridad 2c523f62-c344-4bed-bdb6-51f83c86ec31 600 Kurtis, Mónica M. 3d523ac0-4505-4c6d-b6a5-1dcb51dac967 600 González Ardura, Jessica 5bff2682-a94d-4fac-92cf-809b653fa82e 600 Alonso Redondo, Rubén c748cfef-65bc-4832-b7f5-d11f74ce23bd 600 Ordás Bandera, Carlos Manuel 7381c907-dbd6-48cf-83e4-3630ebcad0cd 600 López Díaz, Luis M. 7b4dea40-9560-41e9-adfc-44cfc79f1b6e 600 McAfee, Darrian 108a6079-a31f-418a-84ba-ba664c420b5c 600 Calopa, Matilde ee4f8b31-e4e5-405e-918f-5ee88321dfbc 600 Carrillo, Fátima fd16c4a9-0063-4ead-9e51-25291a9ac4ba 600 Escamilla-Sevilla, Francisco 6aa10739-9e5f-4f09-8c31-bc72c42553cc 600 Freire-Alvarez, Eric 5c083644-f25c-445d-b463-ce13a727b18b 600 Gómez Esteban, Juan Carlos 1f2ef6e1-656f-4c60-a5df-0a4a053a92f8 600 García Ramos, Rocío eac9adf4-d25c-4246-acff-b23916c95123 600 Luquin Piudo, Mª Rosario df579694-6584-4995-b2f3-8532596bf8ac 600 Martínez Torres, Irene 47f985ef-38a3-4708-86f9-6335d8aa92eb 600 Sesar Ignacio, Ángel 57b23a9b-c75c-4416-977c-d923a726a0b8 600 Martínez Martín, Pablo 3b256da2-afa7-4d7d-91e0-61436565bbac 600 Mir, Pablo 4bc9807f-c2b2-4fa1-a87c-966fcf6b8f12 600 2024-03-14T13:14:13Z 2024-03-14T13:14:13Z 2023-05 1877-7171 http://hdl.handle.net/10259/8826 10.3233/JPD-225073 1877-718X Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p< 0.0001) and EUROHIS-QOL8 (p< 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD. The supplementary material is available in the electronic version of this article: https://dx.doi.org/ 10.3233/JPD-225073. application/pdf eng IOS Press Journal of Parkinson's Disease. 2023, V. 13, n. 3, p. 379-402 https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd225073 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Axial symptoms Cognition MNCD classification Non-motor symptoms Parkinson’s disease Quality of life Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Journal of Parkinson's Disease 13 3 379 402 THUMBNAIL Santos-jpd_2023.pdf.jpg Santos-jpd_2023.pdf.jpg IM Thumbnail image/jpeg 4242 https://riubu.ubu.es/bitstream/10259/8826/4/Santos-jpd_2023.pdf.jpg 4f409fe12d060aa5e24816465e38d62c MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8826/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 914 https://riubu.ubu.es/bitstream/10259/8826/2/license_rdf 24013099e9e6abb1575dc6ce0855efd5 MD5 2 ORIGINAL Santos-jpd_2023.pdf Santos-jpd_2023.pdf application/pdf 520054 https://riubu.ubu.es/bitstream/10259/8826/1/Santos-jpd_2023.pdf 2e8bf088505544573bd8cc0392575a56 MD5 1 10259/8826 oai:riubu.ubu.es:10259/8826 2024-03-15 02:05:28.926 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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