2026-04-29T05:07:13Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88272024-03-16T01:05:27Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
Santos García, Diego
57cc455d-4967-4813-bba9-1c5ea287eb86
600
Laguna, Ariadna
418fdbfa-e199-4b0c-aa41-22b4c49faeed
600
Hernández Vara, Jorge
562507f5-0a69-479c-ae9b-7c57a69a4aa5
600
Deus-Fonticoba, Teresa de
241ee298-45b9-4d5e-a34e-f3083ef0783c
600
Cores Bartolomé, Carlos
9b5e6b7c-ac5d-40e7-98d8-b9845d29da23
600
Feal Painceiras, María
db92b7b5-d3e7-4c23-ba15-12087bf7e0a5
600
Íñiguez Alvarado, María Cristina
216beac8-ca05-42e0-b700-fb22a314a24f
600
García Díaz, Iago
07c2b62a-a147-49f4-bcbb-050bd9236db4
600
Jesús, Silvia
94414864-0f62-4f22-8d66-e96af70069dd
600
Buongiorno, María Teresa
5475728e-1750-4ac1-826f-40de68bac212
600
Planellás, Lluis L.
22ff4e0b-75de-4a8b-82dc-b64f22675be2
600
Cosgaya, Marina
2f66f5ce-1753-448d-836d-4f018398b6fa
600
García Caldentey, Juan
018fd724-d355-4464-9fd6-8b2123a540b5
600
Caballol, Núria
264549f6-e1d7-42b3-a4f6-696fb90b42f0
600
Legarda, Inés
eb1e95ce-6a7b-49ae-b69f-9af9bbae8417
600
Cabo López, Iria
5a3c1be8-1c41-4687-9cb0-cf1874284ede
600
López Manzanares, Lydia
3e221eec-a9b4-41e3-86fd-fe4dae6e5307
600
González Aramburu, Isabel
73cdc52d-8eb7-41d0-9f6e-898136822390
600
Ávila Rivera, María A.
ae1d959d-cd86-4cd6-9a50-ffdd3eaee72a
600
Gómez Mayordomo, Víctor
85c8863b-b0ce-477e-b2ea-dbd37cbfbe1b
600
Nogueira, Víctor
70821c60-b9c4-45ec-a4f2-b7d972c23a09
600
Puente, Víctor
a99a68d7-7362-4046-9561-0bc60158afce
600
Dotor, Julio
5618dab6-87cb-4aa6-8661-2589b4f496b6
600
Borrue, Carmen
293bd583-7502-47d8-9d61-0eb87eb60694
600
Solano Vila, Berta
1fe84e64-c454-4054-b91d-860a9da567ca
600
Álvarez Saúco, María
30efeb28-24da-4c71-951c-4585a9ab000e
600
Vela Desojo, Lydia
1e6a5059-3ea0-4183-9bc6-2c6aba340406
600
Escalante Arroyo, Sonia
e4fb3df0-19aa-41bd-9264-1358e79a22c2
600
Cubo Delgado, Esther
131
600
0000-0003-0018-1182
Carrillo Padilla, Francisco
8ac6c575-2ef8-436e-b7dc-51834ece076a
600
Martínez Castrillo, Juan Carlos
6979aa01-2e50-45aa-8e6d-601542f14eef
600
Sánchez Alonso, Pilar
3c44dc0f-518b-4ab1-b1a3-6a857d653e29
600
Alonso Losada, María Gema
aa797cfa-68df-4808-90fa-8eb05dfb8fbc
600
López Ariztegui, Nuria
296a85f8-6cd9-43ff-b2f6-8c7a0ba2295b
600
Gastón, Itziar
f63aa3b9-5088-4d49-b482-576de9607d97
600
Kulisevsky Bojarsky, Jaume
d2206d09-2cc7-4278-8c83-8daf501d594c
600
Menéndez González, Manuel
03ba235e-6b96-4bec-bcf7-7bf69c5c144f
600
Seijo, Manuel
459a2988-9c1e-46cf-82d7-d70b0184110d
600
Ruíz Martínez, Javier
d1a8cf9d-a541-4cfd-8097-177abecd2ca5
600
Valero, Caridad
2c523f62-c344-4bed-bdb6-51f83c86ec31
600
Kurtis, Mónica M.
3d523ac0-4505-4c6d-b6a5-1dcb51dac967
600
González Ardura, Jessica
5bff2682-a94d-4fac-92cf-809b653fa82e
600
Alonso Redondo, Rubén
c748cfef-65bc-4832-b7f5-d11f74ce23bd
600
Ordás Bandera, Carlos Manuel
7381c907-dbd6-48cf-83e4-3630ebcad0cd
600
López Díaz, Luis M.
7b4dea40-9560-41e9-adfc-44cfc79f1b6e
600
McAfee, Darrian
108a6079-a31f-418a-84ba-ba664c420b5c
600
Martínez Martín, Pablo
3b256da2-afa7-4d7d-91e0-61436565bbac
600
Mir, Pablo
4bc9807f-c2b2-4fa1-a87c-966fcf6b8f12
600
COPPADIS Study Group
939e521a-fb6f-43ac-8b9f-b5515f53a388
600
2024-03-15T07:49:26Z
2024-03-15T07:49:26Z
2023-02
http://hdl.handle.net/10259/8827
10.3390/jcm12041329
2077-0383
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.
COPPADIS and the present study were developed with the help of Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético ( https://fundaciondegen.org/) and Alpha Bioresearch (www.alphabioresearch.com). Also, we received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesión de subvenciones de Proyectos de Investigación en Salud de la convocatoria 2020 de la Acción Estratégica en Salud 2017–2020 por el proyecto “PROGRESIÓN NO MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”) to develop a part of the COPPADIS project.
application/pdf
eng
MDPI
Journal of Clinical Medicine. 2023, V. 12, n. 4, 1329
https://doi.org/10.3390/jcm12041329
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Motor
Non-motor symptoms
Gender
Parkinson’s disease
Quality of life
Sex
Sistema nervioso-Enfermedades
Medicina
Neurología
Nervous system-Diseases
Medicine
Neurology
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Journal of Clinical Medicine
12
4
THUMBNAIL
Santos-jcm_2023.pdf.jpg
Santos-jcm_2023.pdf.jpg
IM Thumbnail
image/jpeg
3554
https://riubu.ubu.es/bitstream/10259/8827/4/Santos-jcm_2023.pdf.jpg
0a0a6fec53f1637362f8a99fcb1a61b2
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
999
https://riubu.ubu.es/bitstream/10259/8827/3/license.txt
b295bcbce42e2caabeb0c623d3860c06
MD5
3
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://riubu.ubu.es/bitstream/10259/8827/2/license_rdf
0175ea4a2d4caec4bbcc37e300941108
MD5
2
ORIGINAL
Santos-jcm_2023.pdf
Santos-jcm_2023.pdf
application/pdf
944032
https://riubu.ubu.es/bitstream/10259/8827/1/Santos-jcm_2023.pdf
d9568fd8d9a49311df439a0bd5f00a02
MD5
1
10259/8827
oai:riubu.ubu.es:10259/8827
2024-03-16 02:05:27.262
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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