2026-04-17T09:37:18Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88292024-03-16T01:05:05Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

00925njm 22002777a 4500 dc Santos García, Diego author Deus-Fonticoba, Teresa de author Cores Bartolomé, Carlos author Feal Painceiras, María author Paz González, José Manuel author Martínez Miró, Cristina author Jesús, Silvia author Aguilar, Miquel author Pastor, Pau author Planellás, Lluis L. author Cosgaya, Marina author García Caldentey, Juan author Caballol, Núria author Legarda, Inés author Hernández Vara, Jorge author Cabo López, Iria author López Manzanares, Lydia author González Aramburu, Isabel author Ávila Rivera, María A. author Gómez Mayordomo, Víctor author Nogueira, Víctor author Puente, Víctor author Dotor, Julio author Borrue, Carmen author Solano Vila, Berta author Álvarez Saúco, María author Vela Desojo, Lydia author Escalante Arroyo, Sonia author Cubo Delgado, Esther author Carrillo Padilla, Francisco author Martínez Castrillo, Juan Carlos author Sánchez Alonso, Pilar author Alonso Losada, María Gema author López Ariztegui, Nuria author Gastón, Itziar author Kulisevsky Bojarsky, Jaume author Blázquez Estrada, Marta author Seijo, Manuel author Ruíz Martínez, Javier author Valero, Caridad author Kurtis, Mónica M. author Fabregues, Oriol de author González Ardura, Jessica author Alonso Redondo, Rubén author Ordás Bandera, Carlos Manuel author López Díaz, Luis M. author McAfee, Darrian author Martínez Martín, Pablo author Mir, Pablo author COPPADIS Study Group author 2023-01 Background and Purpose: Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson’s disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson’s disease and normal cognition (PD-NC). Methods: Patients with PD-NC (total score of >80 on the Parkinson’s Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as “with SCC” and “with VH,” respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of <81. Results: At V0 (n=376, 58.2% males, age 61.14±8.73 years [mean±SD]), the frequencies of VH and SCC were 13.6% and 62.2%, respectively. VH were more frequent in patients with SCC than in those without: 18.8% (44/234) vs 4.9% (7/142), p<0.0001. At V2, 15.2% (57/376) of the patients had developed CI. VH presenting at V0 was associated with a higher risk of CI at V2 (odds ratio [OR]=2.68, 95% confidence interval=1.05–6.83, p=0.0.039) after controlling for the effects of age, disease duration, education, medication, motor and nonmotor status, mood, and PD-CRS total score at V0. Although SCC were not associated with CI at V2, presenting both VH and SCC at V0 increased the probability of having CI at V2 (OR=3.71, 95% confidence interval=1.36–10.17, p=0.011). Conclusions: VH were associated with the development of SCC and CI at the 2-year follow-up in patients with PD-NC. 1738-6586 http://hdl.handle.net/10259/8829 10.3988/jcn.2022.0186 2005-5013 Cognitive impairment Dementia Parkinson’s disease Subjective cognitive complaints Visual hallucinations Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints