2026-06-01T08:54:13Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88312024-03-16T01:05:11Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
Santos García, Diego
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Deus-Fonticoba, Teresa de
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Cores Bartolomé, Carlos
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Feal Painceiras, María
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Íñiguez Alvarado, María Cristina
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Jesús, Silvia
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Buongiorno, María Teresa
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Planellás, Lluis L.
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Cosgaya, Marina
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García Caldentey, Juan
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Caballol, Núria
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Legarda, Inés
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Hernández Vara, Jorge
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Cabo López, Iria
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González Aramburu, Isabel
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Ávila Rivera, María A.
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Gómez Mayordomo, Víctor
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Nogueira, Víctor
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Puente, Víctor
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Dotor, Julio
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Borrue, Carmen
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Solano Vila, Berta
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Álvarez Saúco, María
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Vela Desojo, Lydia
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Escalante Arroyo, Sonia
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Cubo Delgado, Esther
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Carrillo Padilla, Francisco
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Martínez Castrillo, Juan Carlos
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Sánchez Alonso, Pilar
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Alonso Losada, María Gema
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López Ariztegui, Nuria
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Gastón, Itziar
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Kulisevsky Bojarsky, Jaume
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Blázquez Estrada, Marta
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Seijo, Manuel
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Ruíz Martínez, Javier
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Valero, Caridad
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Kurtis, Mónica M.
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Fabregues, Oriol de
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González Ardura, Jessica
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Alonso Redondo, Rubén
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Ordás Bandera, Carlos Manuel
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López Díaz, Luis M.
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McAfee, Darrian
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Martínez Martín, Pablo
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Mir, Pablo
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COPPADIS Study Group
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2024-03-15T08:41:42Z
2024-03-15T08:41:42Z
2023-04
2090-8083
http://hdl.handle.net/10259/8831
10.1155/2023/3104425
2042-0080
Introduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls. Results. The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls; < 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls; < 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR = 1.032; = 0.012), being male (OR = 2.333; < 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1.020; < 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1.012; < 0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR = 1.121; = 0.007) as a predictor of drooling at V2. Conclusion. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.
COPPADIS and the present study were developed with the help of Fundacion Española de Ayuda a la Investigaci ´ on en ´ Enfermedades Neurodegenerativas y/o de Origen Genetico ´ (https://fundaciondegen.org/) and Alpha Bioresearch (https://www.alphabioresearch.com). Also, Te authors received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesion de subvenciones de Proyectos de Investigaci ´ on´ en Salud de la convocatoria 2020 de la Accion Estrat ´ egica en ´ Salud 2017–2020 por el proyecto “PROGRESION NO ´ MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”) to develop a part of the COPPADIS project.
application/pdf
eng
Hindawi
Parkinson's Disease. 2023, V. 2023, p. 1-18
https://doi.org/10.1155/2023/3104425
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Sistema nervioso-Enfermedades
Medicina
Neurología
Nervous system-Diseases
Medicine
Neurology
Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Parkinson's Disease
2023
1
18
THUMBNAIL
Santos-pd_2023.pdf.jpg
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Santos-pd_2023.pdf
Santos-pd_2023.pdf
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10259/8831
oai:riubu.ubu.es:10259/8831
2024-03-16 02:05:11.096
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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