2026-06-01T06:50:45Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88582024-03-21T01:05:20Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Kim, Jonggeol Jeffrey 4c2a07da-4ea8-42a6-849a-345252443db2 600 Vitale, Dan c20c5517-47d3-4ec5-9e0d-b5b8094e559a 600 Véliz Otani, Diego 52691140-b653-483f-a580-f5f7cef58f63 600 Lian, Michelle Mulan f215caa7-62f8-41fb-a15d-f7bbd4ee2fba 600 Heilbron, Karl 7bf14660-a508-4915-94ac-ebe6e785cafc 600 23andMe Research Team ae1ea10a-46e2-4c26-b5fb-afdfaf55e049 600 Iwaki, Hirotaka 7b87e734-633a-466f-8e7f-b1286b271e01 600 Lake, Julie 49dcbaa5-736b-4c1e-8421-d27645ae614a 600 Warly Solsberg, Caroline 8e904c46-9a5b-443c-80c7-cd2ddd964575 600 Leonard, Hampton 9f3cb150-0ff3-4aba-b310-df73cf8a2551 600 Makarious, Mary B. f7036bad-037d-44c6-9e13-848703bb5bfb 600 Tan, Eng-King 1be39354-beaa-4b41-af36-714f6c2df446 600 Singleton, Andrew B. 902b3653-a120-415e-830a-d85737e4d0a6 600 Bandres-Ciga, Sara 3dabc2b3-62e3-4a11-a8a4-b7abc1e55471 600 Noyce, Alastair J. 7192aa51-024a-4f71-b89a-0dd92344ffa9 600 Cubo Delgado, Esther 131 600 0000-0003-0018-1182 Global Parkinson's Genetics Program 0c8091c0-dabf-47bf-9771-dae02754e8e7 600 Blauwendraat, Cornelis 0d6480c9-4afe-47bf-b1c2-70f554a7eaca 600 Nalls, Mike A. 33a8c341-839d-4535-a988-24c98c57b119 600 Nee Foo, Jia 53e30f37-6bba-44fe-aee1-39c6d3fbe285 600 Mata, Ignacio c918f370-f4d7-4776-a10a-308cf05b2959 600 2024-03-20T11:57:55Z 2024-03-20T11:57:55Z 2023-12 1546-1718 http://hdl.handle.net/10259/8858 10.1038/s41588-023-01584-8 1061-4036 Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations. application/pdf eng Springer Nature Nature Genetics. 2024, V. 56, n. 1, p. 27-36 https://doi.org/10.1038/s41588-023-01584-8 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nature Genetics 56 1 27 36 THUMBNAIL Kim-ng_2024.pdf.jpg Kim-ng_2024.pdf.jpg IM Thumbnail image/jpeg 4971 https://riubu.ubu.es/bitstream/10259/8858/4/Kim-ng_2024.pdf.jpg 20a2f178f149c57dbe778fe7da68fa37 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8858/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/8858/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Kim-ng_2024.pdf Kim-ng_2024.pdf application/pdf 5283165 https://riubu.ubu.es/bitstream/10259/8858/1/Kim-ng_2024.pdf a49cfe34ad3e890e4198af878cde3262 MD5 1 10259/8858 oai:riubu.ubu.es:10259/8858 2024-03-21 02:05:20.235 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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