2026-04-27T09:12:39Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/93252024-07-02T00:05:30Zcom_10259_3596com_10259_5086com_10259_2604com_10259_3593col_10259_3597col_10259_3594

Direct synthesis of haloaromatics from nitroarenes via a sequential one-pot Mo-catalyzed reduction/Sandmeyer reaction Hernández Ruiz, Raquel Gómez Gil, Sara Pedrosa Sáez, María de los Remedios Suarez Pantiga, Samuel Sanz Díez, Roberto Química orgánica Biología molecular Chemistry, Organic Molecular biology Herein, we report the direct synthesis of a wide variety of functionalized aromatic bromides, chlorides, iodides, and fluorides from nitroarenes in a sequential one-pot operation. This protocol is based on an air- and moisture-tolerant dioxomolybdenum-catalyzed reduction of nitroaromatics, employing pinacol as a reducing agent, which enables subsequent diazotization and halogenation steps. This methodology represents a step-economical, practical, and alternative procedure for synthesizing haloaromatics directly from nitroaromatics. We gratefully acknowledge the Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033 (PID2020-115789GB-C21) and the Junta de Castilla y León and FEDER (BU049P20) for financial support. R. H.-R. and S. G.-G. thank the Ministerio de Educación for FPU predoctoral contracts. S. S.-P. thanks the Ministerio de Ciencia e Innovación and the “NextGenerationEU”/PRTR EU for a Ramón y Cajal contract (RYC2021-031533-I). 2024-07-01T06:55:37Z 2024-07-01T06:55:37Z 2023-09-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1477-0520 http://hdl.handle.net/10259/9325 10.1039/D3OB01187A 1477-0539 eng Organic & Biomolecular Chemistry. 2023, V. 21, n. 38, p. 7791-7798 https://doi.org/10.1039/D3OB01187A Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf Royal Society of Chemistry https://riubu.ubu.es/bitstream/10259/9325/4/Hernandez-obc_2023.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by-nc/4.0/ RIUBU. Repositorio Institucional de la Universidad de Burgos http://hdl.handle.net/10259/9325