2026-05-11T20:25:59Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/93362024-07-03T00:05:19Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

Synthesis of 4‐Furan‐ and 4‐Pyrrol‐3‐yl‐2H‐chromenes from Naturally‐occurring Compounds by Gold(I)‐Catalyed Domino Reactions Solas Luera, Marta Renedo Peña, Lorena Suárez Pantiga, Samuel Sanz Díez, Roberto Annulation Chromenes Furans Gold Hydroarylation Pyrroles Química orgánica Chemistry, Organic A gold-catalyzed cascade double cyclization reaction has been designed to synthesize heterobiaryl compounds such as furanyl and pyrrolyl 2H-chromenes from bis(alkynyl)-1,2-diols and 1,2-amino alcohols. The starting materials are readily available from biomass platform molecules such as α-hydroxy acids and α-amino acids. The process involves an initial heterocyclodehydration step enabling the formation of the furan or pyrrole ring, followed by an alkyne hydroarylation to form the chromene core. We gratefully acknowledge Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033 (PID2020–115789GB-C21), and Junta de Castilla y León and FEDER (BU049P20) for financial support. M.S. and L.R. thank Junta de Castilla y León (Consejería de Educación) and Fondo Social Europeo for predoctoral contracts. S.S.-P. thanks a Ramón y Cajal (RYC2021-031533-I) contract funded by MCIN/AEI/10.13039/501100011033 and European Union “NextGenerationEU”/PRTR. 2024-07-02T07:48:26Z 2024-07-02T07:48:26Z 2023-05-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1615-4150 http://hdl.handle.net/10259/9336 10.1002/adsc.202300300 1615-4169 eng Advanced Synthesis & Catalysis. 2023, V. 365, n. 12, p. 2049-2056 https://doi.org/10.1002/adsc.202300300 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf Wiley