2026-04-28T13:19:03Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/97782024-12-13T01:05:26Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597

Rodríguez, María R. de4ee4ea-1aad-4fd7-b28a-22371fc05def 600 Balsa, Lucía M. d30c3c8c-dca2-4143-a9ab-8352175d8fff 600 Piro, Oscar Enrique d61bad4c-b7a0-4785-9eee-d1c6c98bbc1c 600 Echeverría, Gustavo A. 2b0d851a-016a-44ac-a770-0d6c895a9477 600 García Tojal, Javier 221 600 0000-0003-3816-0483 Pis Diez, Reinaldo dba891e7-f406-453b-9d51-6d4eb3d488cc 600 León, Ignacio E. 673276ff-bbee-4327-92be-002533b85470 600 Parajón Costa, Beatriz S. 7ef5033b-87a2-4ee0-ac53-eddaa2d60800 600 González Baró, Ana C. 8193c5ec-ef8e-4c67-bbe5-31596f1fbeb2 600 2024-12-12T12:15:27Z 2024-12-12T12:15:27Z 2021-01 http://hdl.handle.net/10259/9778 10.3390/inorganics9020009 2304-6740 A new Cu(II) complex is synthetized by the reaction of copper nitrate and a N-acylhydrazone ligand obtained from the condensation of o-vanillin and 2-thiophecarbohydrazide (H2L). The solid-state structure of [Cu(HL)(H2O)](NO3)·H2O, or CuHL for simplicity, was determined by X-ray diffraction. In the cationic complex, the copper center is in a nearly squared planar environment with the nitrate interacting as a counterion. CuHL was characterized by spectroscopic techniques, including solid-state FTIR, Raman, electron paramagnetic resonance (EPR) and diffuse reflectance and solution UV-Vis electronic spectroscopy. Calculations based on the density functional theory (DFT) assisted the interpretation and assignment of the spectroscopic data. The complex does not show relevant antioxidant activity evaluated by the radical cation of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method, being even less active than the free ligand as a radical quencher. Cytotoxicity assays of CuHL against three human tumor cell lines, namely MG-63, A549 and HT-29, revealed an important enhancement of the effectiveness as compared with both the ligand and the free metal ion. Moreover, its cytotoxic effect was remarkably stronger than that of the reference metallodrug cisplatin in all cancer cell lines tested, a promissory result in the search for new metallodrugs of essential transition metals. This research was funded by CONICET-CCT- La Plata (PIP 0651 and 034), ANPCyT (PICT 2016-1574) and UNLP (11/X041, 11/X837 and 11/X857), Argentina, and also by Consejería de Educación of Junta de Castilla y León BU022G18, Junta de Castilla y León and FEDER BU291P18 and BU049P20, Ministerio de Economía y Competitividad, CTQ2016-75023-C2-1-P, and Ministerio de Ciencia, Innovación y Universidades, CTQ(QMC) RED2018-102471-T, MultiMetDrugs Network (Spain). application/pdf eng MDPI Inorganics. 2021, V. 9, n. 2, p. 9 https://doi.org/10.3390/inorganics9020009 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Copper(II) complex N-acylhydrazone Spectroscopy XRD crystal structure DFT calculations Anti-cancer activity Química inorgánica Chemistry, Inorganic Synthesis, Crystal Structure, Spectroscopic Characterization, DFT Calculations and Cytotoxicity Assays of a New Cu(II) Complex with an Acylhydrazone Ligand Derived from Thiophene info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Inorganics 9 2 9 THUMBNAIL Rodriguez-I_2021.pdf.jpg Rodriguez-I_2021.pdf.jpg IM Thumbnail image/jpeg 3552 https://riubu.ubu.es/bitstream/10259/9778/4/Rodriguez-I_2021.pdf.jpg 430d0fba8b78daba6c043abbf71144bc MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/9778/3/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/9778/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Rodriguez-I_2021.pdf Rodriguez-I_2021.pdf application/pdf 2559447 https://riubu.ubu.es/bitstream/10259/9778/1/Rodriguez-I_2021.pdf cda5e63de9bbebd52e33fd7dba4dc2cd MD5 1 10259/9778 oai:riubu.ubu.es:10259/9778 2024-12-13 02:05:26.324 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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