2026-04-17T11:32:16Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/97932024-12-18T01:05:26Zcom_10259_6168com_10259_5086com_10259_2604col_10259_6169

00925njm 22002777a 4500 dc Gómez Cuadrado, Laura author Tracey, Natasha author Ma, Ruoyu author Qian, Binzhi author Brunton, Valerie G. author 2017-09 Metastasis is the spread of cancer cells from a primary tumor to distant sites within the body to establish secondary tumors. Although this is an inefficient process, the consequences are devastating as metastatic disease accounts for >90% of cancer-related deaths. The formation of metastases is the result of a series of events that allow cancer cells to escape from the primary site, survive in the lymphatic system or blood vessels, extravasate and grow at distant sites. The metastatic capacity of a tumor is determined by genetic and epigenetic changes within the cancer cells as well as contributions from cells in the tumor microenvironment. Mouse models have proven to be an important tool for unraveling the complex interactions involved in the metastatic cascade and delineating its many stages. Here, we critically appraise the strengths and weaknesses of the current mouse models and highlight the recent advances that have been made using these models in our understanding of metastasis. We also discuss the use of these models for testing potential therapies and the challenges associated with the translation of these findings into the provision of new and effective treatments for cancer patients. 1754-8403 http://hdl.handle.net/10259/9793 10.1242/dmm.030403 1754-8411 Cancer Metastasis Mouse models Stroma Mouse models of metastasis: progress and prospects