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oai:riubu.ubu.es:10259/98072024-12-20T01:05:28Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597

Burgos López, Y. 3e65d86e-2d29-437b-be82-1d879ddb5356 600 Balsa, Lucía M. d30c3c8c-dca2-4143-a9ab-8352175d8fff 600 Piro, Oscar Enrique d61bad4c-b7a0-4785-9eee-d1c6c98bbc1c 600 León, Ignacio E. 673276ff-bbee-4327-92be-002533b85470 600 García Tojal, Javier 221 600 0000-0003-3816-0483 Echeverría, Gustavo A. 2b0d851a-016a-44ac-a770-0d6c895a9477 600 González Baró, Ana C. 8193c5ec-ef8e-4c67-bbe5-31596f1fbeb2 600 Parajón Costa, Beatriz S. 7ef5033b-87a2-4ee0-ac53-eddaa2d60800 600 2024-12-18T12:06:39Z 2024-12-18T12:06:39Z 2022-02 0277-5387 http://hdl.handle.net/10259/9807 10.1016/j.poly.2021.115621 Two new penta-coordinated copper(II) hydrazone coordination compounds with 2,2́ bipyridine (I) or 1,10 phenanthroline (II) as coligands are synthesized and characterized in the solid state and in solution by spectroscopic methods (FTIR, Raman, UV–vis, EPR). Single crystal X-ray studies show that they have closely related molecular structures with the copper center in a distorted square pyramidal O2N3 environment. The N-acylhydrazone, 4-hydroxy-NŃ-(E)2-hydroxy-3-methoxybenzylidene]benzohydrazide, H2L, coordinates tridentate through its ONO donor atoms as monoanion (HL-) in the cationic complex (I), [Cu(HL)(bipy)](NO3). During the period that takes the synthesis reaction of compound (II), [Cu(L)(o-phen)] to complete, keto-amine to enol-imine tautomerization of H2L occurs and the hydrazone coordinates tridentate as dianionic ligand (L2-). The fivefold coordination sphere of the complexes is completed with the nitrogen atoms of the respective coligands. Cytotoxicity studies against bone (MG-63, IC50(I) = 5.6 ± 1.0 , IC50(II) = 3.5 ± 0.3), breast (MCF7, IC50(I) = 10.8 ± 1.9, IC50(II) = 4.0 ± 1.3), (MDA-MB-231, IC50(I) = 11.4 ± 0.6, IC50(II) = 5.3 ± 0.2) and lung cancer cells (A549, IC50(I) = 7.7 ± 0.7, IC50(II) = 7.0 ± 0.4) reveals increased effectiveness of both complexes compared with the free ligand, the copper nitrate salt and the reference metallodrug cisplatin (CDDP). This work was supported by CONICET-CCT-La Plata (PIP: 0340, 0651), UNLP (Grant: 11/X673, 11/041, 11/857), ANPCyT (PICT 2016–1574), Argentina, and by Junta de Castilla y León and FEDER BU291P18 and BU049P20, Ministerio de Economía y Competitividad CTQ2016-75023-C2-1-P, Fundación Bancaria Caixa D. Etalvis I Pensions de Barcelona La Caixa-UBU001 and European Union H2020-LC-SC3-2020-NZE-RES-CC Nefertiti Project, of Spain. application/pdf eng Elsevier Polyhedron. 2022, V. 213, p. 115621 https://doi.org/10.1016/j.poly.2021.115621 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Cu(II)-complexes Hydrazones Spectroscopy Crystal structure Anticancer activity Química analítica Ingeniería Química Chemistry, Analytic Chemical engineering Tridentate acylhydrazone copper(II) complexes with heterocyclic bases as coligands. Synthesis, spectroscopic studies, crystal structure and cytotoxicity assays info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Polyhedron 213 115621 THUMBNAIL burgos-polyhedron_2022.pdf.jpg burgos-polyhedron_2022.pdf.jpg IM Thumbnail image/jpeg 3615 https://riubu.ubu.es/bitstream/10259/9807/4/burgos-polyhedron_2022.pdf.jpg 4f41342944b316faed103b0d4d31d07c MD5 4 Burgos-polyhedron_2022.pdf.jpg Burgos-polyhedron_2022.pdf.jpg IM Thumbnail image/jpeg 4075 https://riubu.ubu.es/bitstream/10259/9807/6/Burgos-polyhedron_2022.pdf.jpg f083e1ffd25602e358c56bf684153802 MD5 6 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/9807/3/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/9807/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Burgos-polyhedron_2022.pdf Burgos-polyhedron_2022.pdf application/pdf 1266264 https://riubu.ubu.es/bitstream/10259/9807/5/Burgos-polyhedron_2022.pdf 551897a33fcc03dd4b27638aa8fe1325 MD5 5 10259/9807 oai:riubu.ubu.es:10259/9807 2024-12-20 02:05:28.884 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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