RT info:eu-repo/semantics/article
T1 The evolution and changing ecology of the African hominid oral microbiome
A1 Fellows Yates, James A.
A1 Velsko, Irina M.
A1 Aron, Franziska
A1 Posth, Cosimo
A1 Hofman, Courtney A.
A1 Austin, Rita M.
A1 Parker, Cody E.
A1 Mann, Allison E.
A1 Nägele, Kathrin
A1 Arthur, Kathryn Weedman
A1 Arthur, John W.
A1 Bauer, Catherine C.
A1 Crevecoeur, Isabelle
A1 Cupillard, Christophe
A1 Curtis, Matthew C.
A1 Dalén, Love
A1 Díaz-Zorita Bonilla, Marta
A1 Díez Fernández-Lomana, Juan Carlos
A1 Drucker, Dorothée G.
A1 Escribano Escrivá, Elena
A1 Francken, Michael
A1 Gibbon, Victoria E.
A1 González Morales, Manuel
A1 Grande Mateu, Ana
A1 Harvati, Katerina
A1 Henry, Amanda G.
A1 Humphrey, Louise
A1 Menéndez, Mario
A1 Mihailović, Dušan
A1 Peresani, Marco
A1 Rodríguez Moroder, Sofía
A1 Roksandic, Mirjana
A1 Rougier, Hélène
A1 Sázelová, Sandra
A1 Stock, Jay T.
A1 Straus, Lawrence Guy
A1 Svoboda, Jiří
A1 Teßmann, Barbara
A1 Walker, Michael J.
A1 Power, Robert C.
A1 Lewis, Cecil M.
A1 Sankaranarayanan, Krithivasan
A1 Guschanski, Katerina
A1 Wrangham, Richard W.
A1 Dewhirst, Floyd E.
A1 Salazar-García, Domingo C.
A1 Krause, Johannes
A1 Herbig, Alexander
A1 Warinner, Christina
K1 Dental calculus
K1 Microbiome
K1 Neanderthal
K1 Primate
K1 Salivary amylase
K1 Antropología cultural y social
K1 Ethnology
K1 Evolución humana
K1 Human evolution
K1 Paleolítico
K1 Paleolithic period
AB The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing ecology of the human oral microbiome, we analyzed 124 dental biofilm metagenomes from humans, including Neanderthals and Late Pleistocene to present-day modern humans, chimpanzees, and gorillas, as well as New World howler monkeys for comparison. We find that a core microbiome of primarily biofilm structural taxa has been maintained throughout African hominid evolution, and these microbial groups are also shared with howler monkeys, suggesting that they have been important oral members since before the catarrhine–platyrrhine split ca. 40 Mya. However, community structure and individual microbial phylogenies do not closely reflect host relationships, and the dental biofilms of Homo and chimpanzees are distinguished by major taxonomic and functional differences. Reconstructing oral metagenomes from up to 100 thousand years ago, we show that the microbial profiles of both Neanderthals and modern humans are highly similar, sharing functional adaptations in nutrient metabolism. These include an apparent Homo-specific acquisition of salivary amylase-binding capability by oral streptococci, suggesting microbial coadaptation with host diet. We additionally find evidence of shared genetic diversity in the oral bacteria of Neanderthal and Upper Paleolithic modern humans that is not observed in later modern human populations. Differences in the oral microbiomes of African hominids provide insights into human evolution, the ancestral state of the human microbiome, and a temporal framework for understanding microbial health and disease.
PB National Academy of Sciences
SN 0027-8424
YR 2021
FD 2021-05
LK https://hdl.handle.net/10259/11181
UL https://hdl.handle.net/10259/11181
LA eng
NO Research at the De Nadale Cave is coordinated by theUniversity of Ferrara within the framework of a project supported by the Min-istry of Culture–Western Veneto Archaeological Superintendence, the Soprin-tendenza Archeologia, belle Arti e Paesaggio per le Provincie di Verona, Rovigoe Vicenza (SABAP), and the Zovencedo Municipality, financed by the H. Ober-maier Society, local private companies (RAASM and Saf), and local sponsors. TheCalleva Foundation supported the excavation and research during which sam-pling of the Taforalt calculus was carried out. This project was funded by grantsfrom the US National Science Foundation (NSF) (BSC-1516633 to C.W. andC.M.L.; BSC-1027607 to K.W.A, M.C.C., and J.W.A.; SBR-0416125 to R.W.W.),the US National Institutes of Health (NIH) (2R01 GM089886 to C.M.L., C.W.,and K.S.; R37DE016937 and R01DE024468 to F.E.D.), the European ResearchCouncil (ERC) (ERC-STG 677576 “HARVEST” to A.G.H.; ERC-CG 617627 “ADaPt”to J.T.S.), the Deutsche Forschungsgemeinschaft (DFG FOR 2237 to K.H.; EXC2051-390713860 to C.W.), the National Research Foundation of South Africa(NRF 115257 and 12081 to V.E.G.), the Natural Sciences and Engineering Re-search Council of Canada (RGPIN-2017-04702 and RGPIN-2019-04113 to M.R.),Czech National Institutional Support (RVO 68081758 to S.S.), the Ministry ofCulture and Information and the Ministry of Education, Science and Technolog-ical Development of the Republic of Serbia (177023 to D.M.), Junta de Castilla yLeón (BU028A09 to J.C.D.F-L.), the Swedish Research Council Formas (2016-00835 and 2019-00275 to K.G.), the University of South Florida, the Universityof Oklahoma, the Werner Siemens Foundation (Paleobiotechnology to C.W.),and the Max Planck Society.
DS Repositorio Institucional de la Universidad de Burgos
RD 19-abr-2026