RT info:eu-repo/semantics/article
T1 Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation
A1 Howard, Kristen R.
A1 Prado‐Nóvoa, Olalla
A1 Zorrilla Revilla, Guillermo
A1 Laskaridou, Eleni
A1 Reid, Glen R.
A1 Marinik, Elaina L.
A1 Stamatiou, Marina
A1 Hambly, Catherine
A1 Davy, Brenda M.
A1 Speakman, John R.
A1 Davy, Kevin P.
K1 Physical activity
K1 Energy expenditure
K1 Doubly-labelled water
K1 Constraint
K1 Compensation
K1 Fisiología humana
K1 Human physiology
K1 Ejercicio físico
K1 Exercise
K1 Metabolismo energético
K1 Energy metabolism
AB The prevailing linear model of physical activity (PA) and total energy expenditure (TEE) has been challenged by models that predict an upper limit of TEE linked to a compensatory reduction elsewhere in the energy budget in response to increased PA. We determined the equation of best fit between PA and TEE and explored relationships between PA and behavioral and physiological compensation. Using linear and nonlinear modeling, we observed a positive linear relationship between PA and TEE either without or after adjustment for fat-free mass (R2= 0.3492, TEE = 0.00685*PA + 7.124: R2=0.3667, TEE_ADJ(FFM) = 0.00511*PA + 8.598). Higher PA was associated with lower sedentary time (R2= 0.7207, %SPA= −0.0211*X + 91.261). There was no association between PA, TEE, or resting metabolic rate and adjusted biomarkers of immune, reproductive, or thyroid function after Bonferroni correction. The findings of this observational study do not support the constrained/compensated model but affirm the conventional additive relationship between PA and TEE across a broad range of PA levels.
PB National Academy of Sciences
SN 0027-8424
YR 2025
FD 2025-10
LK https://hdl.handle.net/10259/11212
UL https://hdl.handle.net/10259/11212
LA eng
NO K.R.H. is funded by a Virginia Tech Translational Obesity Research Interdisciplinary Graduate Education Predoctoral Fellowship, O.P.-N. is funded by a Virginia Tech Presidential Postdoctoral Fellowship, and G.Z.-R. is funded by Next Generation European Union funds Margarita Salas Postdoctoral Fellowship.
DS Repositorio Institucional de la Universidad de Burgos
RD 11-may-2026