RT info:eu-repo/semantics/article
T1 Genome-Wide association study to identify genetic markers associated with Campylobacter jejuni motility
A1 Ortega Sanz, Irene
A1 Rovira Carballido, Jordi
A1 Megías, Gregoria
A1 Rivero Pérez, Maria Dolores
A1 Melero Gil, Beatriz
K1 Genomics
K1 Bacterial GWAS
K1 Phenotype
K1 Pangenome
K1 SNP
K1 Genetic marker
K1 Microbiología
K1 Microbiology
K1 Genética
K1 Genetics
AB The ability of Campylobacter jejuni to survive and persist under harsh conditions is linked to the presence of flagella. This structure promotes the motility of the bacteria towards their optimum environment. The aim of this study was to examine the genetic basis for motility within 136 C. jejuni isolates through two different Genome-Wide Association Studies, gene presence/absence and Single Nucleotide Polymorphisms (SNPs). The motility phenotype was widely distributed across the phylogeny with large intra-lineage swarming performance variabilities. Accessory genes significantly associated with motility were found in four key genomic regions. One of these regions affected the Cj0727-Cj0733 operon, that encodes a putative ABC transporter system for phosphate uptake, while other influenced the capsule biosynthesis locus. Multiple SNPs mostly linked to increased motility were also discovered in clusters of genes, with special relevance to transport and membrane proteins. Therefore, the capsule and membrane composition might influence nutrient transfer, further impacting the protonmotive force that drives flagellar motor rotation in C. jejuni. The study provides novel genetic markers with a potential role in the motility phenotype of the pathogen.
PB Elsevier
SN 0882-4010
YR 2025
FD 2025-08
LK https://hdl.handle.net/10259/11287
UL https://hdl.handle.net/10259/11287
LA eng
NO This work was supported by “La Caixa” Foundation and Caja Burgos Foundation [LCF/PR/PR18/51130007], and the Ministry of Education of the Government of Castilla y León [BU064P20]. Ortega-Sanz I received a predoctoral grant from the Junta de Castilla y León, cofinanced by the Ministry of Education of the Government of Castilla y León and the European Social Fund.
DS Repositorio Institucional de la Universidad de Burgos
RD 29-abr-2026