RT info:eu-repo/semantics/article
T1 Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection
A1 Fernandez Becerra, Carmen
A1 Lelievre, Joel
A1 Ferrer, Mireia
A1 Antón Fidalgo, Nuria
A1 Thomson, Richard
A1 Peligero, Cristina
A1 Almela, Maria Jesus
A1 Lacerda, Marcus VG
A1 Herreros, Esperanza
A1 del Portillo, Hernando A
K1 CD34+ human haematopoietic stem cells
K1 NIH 3T3 cells
K1 Plasmodium
K1 Hematología
K1 Hematology
K1 Salud
K1 Health
K1 Parasitología
K1 Parasitology
AB The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34+ hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites.
PB Instituto Oswaldo Cruz, Ministério da Saúde
SN 0074-0276
YR 2013
FD 2013-09
LK https://hdl.handle.net/10259/11295
UL https://hdl.handle.net/10259/11295
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 28-abr-2026