RT info:eu-repo/semantics/article
T1 Phototoxicity of cyclometallated Ir(III) complexes bearing a thio-bis-benzimidazole ligand, and its monodentate analogue, as potential PDT photosensitisers in cancer cell killing
A1 Martínez Alonso, Marta
A1 Jones, Callum G.
A1 Shipp, James D.
A1 Chekulaev, Dimitri
A1 Bryant, Helen E.
A1 Weinstein, Julia A.
K1 PDT
K1 Anticancer drugs
K1 Iridium
K1 Phototoxicity
K1 Fotoquimioterapia
K1 Photochemotherapy
K1 Cáncer-Tratamiento
K1 Cancer-Treatment
AB Two novel cyclometallated iridium(III) complexes have been prepared with one bidentate or two monodentate imidazole-based ligands, 1 and 2, respectively. The complexes showed intense emission with long lifetimes of the excited state. Femtosecond transient absorption experiments established the nature of the lowest excited state as 3IL state. Singlet oxygen generation with good yields (40% for 1 and 82% for 2) was established by detecting 1O2 directly, through its emission at 1270 nm. Photostability studies were also performed to assess the viability of the complexes as photosensitizers (PS) for photodynamic therapy (PDT). Complex 1 was selected as a good candidate to investigate light-activated killing of cells, whilst complex 2 was found to be toxic in the dark and unstable under light. Complex 1 demonstrated high phototoxicity indexes (PI) in the visible region, PI > 250 after irradiation at 405 nm and PI > 150 at 455 nm, in EJ bladder cancer cells.
PB Springer
SN 0949-8257
YR 2024
FD 2024-02
LK https://hdl.handle.net/10259/11325
UL https://hdl.handle.net/10259/11325
LA eng
NO This research was supported by University of Sheffield, Rosetrees Trust grant number M698 Wellcome Trust grant WT093134AIA and MRC SHIMA award MR/K015753/1. M.M. acknowledges the support from the Fundación Alfonso Martín Escudero for her postdoctoral grant. JAW is grateful for the Leverhulme Trust senior research fellowship. We thank the EPSRC for funding for the Lord Porter Laser Laboratory.
DS Repositorio Institucional de la Universidad de Burgos
RD 27-abr-2026