RT info:eu-repo/semantics/article
T1 Testing of black-carrots-derived fluorescence imaging and anti-metastatic potential
A1 Algarra, Manuel
A1 Carrillo Pérez, Celia
A1 Nešić, Maja D.
A1 Tričković, Jelena Filipović
A1 Žakula, Jelena
A1 Korićanac, Lela
A1 Jiménez-Jiménez, José
A1 Rodriguez-Castellón, Enrique
A1 Bandosz, Teresa J.
A1 Petković, Marijana
A1 Soto, Juan
K1 Carbon Dots
K1 Anthocyanins
K1 Black carrot
K1 Fluorescence
K1 Cell imaging
K1 Melanoma therapy
K1 Materiales nanoestructurados
K1 Nanostructured materials
K1 Melanoma-Tratamiento
K1 Melanoma-Treatment
AB This paper explains the basis for the excitation energy-independent fluorescence emission of biomass-derived carbon dots (CDs) and shows that these CDs have excellent anti-melanoma and anti-metastatic potential. Additionally, we demonstrate that the black carrots´-derived CDs can be exploited as cell cycle-sensing agents, because of the interaction with chromatin material. Besides their optical properties, fluorescent CDs have gained increased attention for image-guided cancer treatment due to their water solubility, environmental friendliness, affordability, ease of synthesis, and primary biocompatibility. CDs have excellent photostability, determined by their precursors and synthesis pathways. In this study, CDs with chemically homogenous surface functional groups were made using a hydrothermal technique from black carrot extract, an anthocyanin-rich substance derived from biomass. The anti-cancer and anti-metastatic properties of black carrot-derived CDs can be attributed to flavylium cations on the surface, spherical forms, and high water dispersibility. Most importantly, these CDs demonstrate a stable emission at a single wavelength, 612 nm, independent of the excitation energy, which we have explained theoretically for the first time.
PB Elsevier
SN 0022-2860
YR 2024
FD 2024-03
LK https://hdl.handle.net/10259/11463
UL https://hdl.handle.net/10259/11463
LA eng
NO Authors thank to Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033) though the projects PID2021-122613OB-I00 and PID2021-126235OB-C32 and P18-RT-4592 of Junta de Andalucía and FEDER funds, and the Ministry of Science, Technological Development, and Innovation of the Republic of Serbia (grant 451-03-47/2023-01/200017).
DS Repositorio Institucional de la Universidad de Burgos
RD 16-may-2026