RT info:eu-repo/semantics/article
T1 Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes
A1 Martínez González, Raúl
A1 Rubio Presa, Rubén
A1 Pedrosa Sáez, María de los Remedios
A1 Suárez Pantiga, Samuel
A1 Sanz Díez, Roberto
K1 Catalysis
K1 Molybdenum
K1 Nitroarenes
K1 N-polyheterocycles
K1 Tandem processes
K1 Química orgánica
K1 Chemistry, Organic
AB The direct preparation of nitrogen-containing polyaromatic heterocycles in a single operational step from readily availablenitroarenes represents an attractive and sustainable alternative to traditional multistep approaches. In this context, this workdescribes an efficient and versatile methodology for the synthesis of fused N-polyheterocyclic scaffolds from functionalizednitroarenes and aldehydes catalyzed by dioxomolybdenum(VI) complexes and employing pinacol as a readily available andenvironmentally benign reductant. The protocol integrates nitro reduction, imine formation, and intramolecular cyclization ina single operational sequence. Careful fine-tuning of the reaction conditions proved crucial to minimizing competing pathways.This molybdenum-catalyzed strategy exhibits broad substrate scope, accommodating aromatic, aliphatic, and α,β-unsaturatedaldehydes, and enabling access to a variety of pharmaceutically relevant frameworks, such as pyrrolo[1,2-a]quinoxalines,indoloquinoxalines, γ-carbolines, imidazoquinolines, and phenanthridines.
PB Wiley
SN 2193-5807
YR 2026
FD 2026-05
LK https://hdl.handle.net/10259/11626
UL https://hdl.handle.net/10259/11626
LA eng
NO We gratefully acknowledge Ministerio de Ciencia, Innovación y Universidades (PID2023-148198NB-C21) and Junta de Castilla y León and FEDER (BU028P23) for financial support. Raúl Martínez-González thanks Junta de Castilla y León for a predoctoral contract. Samuel Suárez-Pantiga thanks a Ramón y Cajal (RYC2021-031533-I) contract funded by MICIN/AEI/10.13039/501100011033 and European Union “NextGenerationEU”/PRTR.
DS Repositorio Institucional de la Universidad de Burgos
RD 28-may-2026